Chronic exposure to cannabidiol induces reproductive toxicity in male Swiss mice

Journal of Applied Toxicology : JAT
Renata K CarvalhoRenata Mazaro-Costa

Abstract

Children and adults with frequent and severe episodes of epilepsy that do not respond to standard treatments (such as carbamazepine, phenytoin and valproate) have long been prescribed cannabidiol (CBD) as an anticonvulsant drug. However, the safety of its chronic use in relation to reproduction has not been fully examined. This study aimed to assess the effects of chronic CBD exposure on the male reproductive system. CBD was orally administered to 21-day-old male Swiss mice at doses of 15 and 30 mg kg-1 daily (CBD 15 and 30 groups, respectively), with a control group receiving sunflower oil, for 34 consecutive days. After a 35 day recovery period, the following parameters were evaluated: weight of reproductive organs, testosterone concentration, spermatogenesis, histomorphometry, daily sperm production and its morphology. The CBD 30 group had a 76% decrease in total circulating testosterone, but it remained within the physiological normal range (240-1100 ng dl-1 ). CBD treatment induced a significant increase in the frequency of stages I-IV and V-VI of spermatogenesis, and a decrease in the frequency of stages VII-VIII and XII. A significant decrease in the number of Sertoli cells was observed only in the CBD 30 group. In both ...Continue Reading

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Citations

Jul 18, 2019·Journal of Applied Toxicology : JAT·Renata K CarvalhoRenata Mazaro-Costa
Feb 23, 2019·Journal of Palliative Medicine·April Christensen, Jennifer Pruskowski
Jun 5, 2019·Current Neuropharmacology·Marilyn A HuestisFrancesco Paolo Busardò
Oct 20, 2018·Journal of Applied Toxicology : JAT·Renata K CarvalhoRenata Mazaro-Costa
May 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laura E EwingIgor Koturbash
Dec 2, 2020·International Journal of Molecular Sciences·Gianna RossiMauro Maccarrone
Feb 23, 2021·Frontiers in Pharmacology·Cássio Morais LossVanessa Costhek Abílio
Aug 18, 2020·Journal of Medicinal Chemistry·Kathryn M NelsonGuido F Pauli
Nov 30, 2021·Journal of Dietary Supplements·Paul ClaytonNathasha Bogoda
Jan 7, 2022·Critical Reviews in Food Science and Nutrition·Gonzalo AstrayJesus Simal-Gandara

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