Chronic exposure to chlorpyrifos triggered body weight increase and memory impairment depending on human apoE polymorphisms in a targeted replacement mouse model

Physiology & Behavior
Fiona Peris-SampedroM T Colomina

Abstract

Despite restrictions on their use, humans are still constantly exposed to organophosphates (OPs). A huge number of studies have ratified the neurotoxic effects of chlorpyrifos (CPF) and suggested its association with neurodegenerative diseases, but data are still scarce. Human apolipoprotein E (apoE) plays an important role in lipid transport and distribution. In humans, the apoE4 isoform has been linked to an increased risk of Alzheimer's disease (AD). ApoE3 is the most prevalent isoform worldwide, and has been often established as the healthful one. The current study, performed in targeted replacement (TR) adult male mice, aimed to inquire whether genetic variations of the human apoE respond differently to a chronic dietary challenge with CPF. At four/five months of age, mice carrying apoE2, apoE3 or apoE4 were pair-fed a diet supplemented with CPF at 0 or 2mg/kg body weight/day for 13weeks. Cholinergic signs were monitored daily and body weight changes weekly. In the last week of treatment, learning and memory were assessed in a Barnes maze task. Dietary CPF challenge increased body weight only in apoE3 mice. Differences in the acquisition and retention of the Barnes maze were attributed to apoE genetic differences. Our resu...Continue Reading

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Citations

Jul 15, 2015·Environmental Research·Fiona Peris-SampedroMaria Teresa Colomina
Apr 24, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fiona Peris-SampedroMaria Teresa Colomina
Aug 3, 2016·International Journal of Environmental Research and Public Health·Francesca NappiSilvia Savastano
Jul 30, 2020·The Biochemical Journal·Robert M GutgesellAlison C Holloway
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Rui-Ming LiuJiu-Chiuan Chen
Jul 18, 2020·Journal of Alzheimer's Disease : JAD·Kristen R HollingerBarbara S Slusher
Feb 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jordi BlancoDomènec J Sánchez
Feb 8, 2018·The Journal of Steroid Biochemistry and Molecular Biology·Valentina PomattoPatrizia Bovolin
Aug 26, 2018·Toxicology·Sean X Naughton, Alvin V Terry
Jul 4, 2020·Molecular and Cellular Endocrinology·Xiao-Min RenBruce Blumberg

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