Chronic exposure to cigarette smoke causes extrapulmonary abnormalities in rats

Environmental Toxicology and Pharmacology
Yoshiyuki KamiideToshihiko Yada

Abstract

Pathophysiological features of chronic obstructive pulmonary disease (COPD) include systemic abnormalities, such as weight loss and skeletal muscle wasting. Although cigarette smoke (CS) is a major risk factor in COPD, the systemic effects of CS exposure remain to be elucidated. In this study, rats were exposed to CS or smoke-free air for 12 weeks. CS-exposed rats developed emphysema and had significantly lower body weight and food intake than control rats. The plasma ghrelin levels significantly increased with an upregulation of gastric ghrelin mRNA expression induced by CS exposure. Further, we observed low plasma insulin-like growth factor-1 levels and high tumor necrosis factor-α levels. A significant reduction of skeletal muscle strength and an increase in the mRNA expression of catabolic factors was observed in CS-exposed rats. These results indicated that chronic CS exposure induced not only pulmonary emphysema but also systemic abnormalities related to muscle catabolism associated with inflammatory responses.

References

Feb 1, 1979·Toxicology and Applied Pharmacology·H A Tilson, P A Cabe
Dec 1, 1987·European Journal of Clinical Investigation·R Tocco-BradleyB R Bistrian
Sep 16, 1988·JAMA : the Journal of the American Medical Association·P HajekM Belcher
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·A M ScholsE F Wouters
Sep 11, 2001·American Journal of Respiratory and Critical Care Medicine·D E O'DonnellK A Webb
Aug 15, 2002·The Journal of Endocrinology·N MurakamiK Kangawa
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Alvar G N AgustíXavier Busquets
Mar 1, 2003·The European Respiratory Journal·A G N AgustíX Busquets
Apr 23, 2003·The Practitioner·Eric Livingston, Neil C Thomson
May 17, 2003·BMJ : British Medical Journal·David Price, Martin Duerden
Jul 11, 2003·Chest·Richard DebigaréFrançois Maltais
Sep 16, 2003·Neurotoxicology and Teratology·Jacques P J MaurissenKenneth E Stebbins
Mar 5, 2004·The New England Journal of Medicine·Bartolome R CelliHoward J Cabral
Jul 24, 2004·American Journal of Respiratory and Critical Care Medicine·Takefumi ItohHiroshi Kimura
Oct 28, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hui ChenMargaret J Morris
Apr 6, 2006·Clinical Chemistry·Demosthenes BourosAsterios Kukuvitis
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Robert A FrostCharles H Lang
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Mariève DoucetFrançois Maltais
May 15, 2007·Chest·Dilyara G YanbaevaEmiel F M Wouters
Jan 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew ChurgJoanne L Wright
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joanne L WrightAndrew Churg
Aug 5, 2008·Pulmonary Pharmacology & Therapeutics·Brendan J Canning, Joanne L Wright
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Harry R GoskerAnnemie M W J Schols
Jun 4, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·María López-MenduiñaAsunción López-Calderón
Feb 2, 2012·The Journal of Toxicological Sciences·Koichi TomodaHiroshi Kimura
Sep 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Michele Zoli, Marina R Picciotto

❮ Previous
Next ❯

Citations

Oct 9, 2015·American Journal of Respiratory Cell and Molecular Biology·Nele CielenGhislaine N Gayan-Ramirez
Nov 18, 2017·Journal of Complementary & Integrative Medicine·Khaled M M Koriem, Mahmoud S Arbid
Aug 9, 2020·PloS One·Ana Caroline Rippi MorenoPatricia Monteiro Seraphim
Jul 19, 2018·BioMed Research International·Zheng WangXiaoju Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.