Chronic exposure to dietary antibiotics affects intestinal health and antibiotic resistance gene abundance in oriental river prawn (Macrobrachium nipponense), and provokes human health risk

The Science of the Total Environment
Shengming SunXianping Ge

Abstract

Antibiotics are employed worldwide to treat diseases of humans and other animals, but most antibiotics and their secondary metabolites are discharged into the aquatic environment, and these pollutants are emerging as a severe threat to human health. However, the systematic effects of dietary antibiotics on intestinal health in crustaceans and the associated risk to human health have not been thoroughly investigated, especially the effects on growth, immune responses, intestinal health, and the abundance of antibiotic residues and antibiotic resistance genes (ARGs). In the present work, two typical antibiotics (sulfamethoxazole and oxytetracycline) were administered orally to juvenile oriental river prawn (Macrobrachium nipponense) for eight weeks to mimic long-term use of antibiotics at legal aquaculture doses. The results indicate that dietary exposure to antibiotics significantly inhibited the growth performance of prawns, suppressed immunological parameters, and caused higher mortality in prawns challenged with Aeromonas hydrophila. Furthermore, prawns fed a diet containing antibiotics displayed a decrease in the number of intestinal goblet cells and lower digestive enzyme activity, as well as impaired intestine antioxidant ...Continue Reading

Citations

Mar 7, 2021·The Science of the Total Environment·Dongsheng ZhengYanling Zheng

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