Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype

Neuromolecular Medicine
Rena C TabataC A Shaw

Abstract

Epidemiological studies of the Guamanian variants of amyotrophic lateral sclerosis (ALS) and parkinsonism, amyotrophic lateral sclerosis-parkinsonism dementia complex (ALS-PDC), have shown a positive correlation between consumption of washed cycad seed flour and disease occurrence. Previous in vivo studies by our group have shown that the same seed flour induces ALS and PDC phenotypes in out bred adult male mice. In vitro studies using isolated cycad compounds have also demonstrated that several of these are neurotoxic, specifically, a number of water insoluble phytosterol glucosides of which beta-sitosterol beta-D: -glucoside (BSSG) forms the largest fraction. BSSG is neurotoxic to motor neurons and other neuronal populations in culture. The present study shows that an in vitro hybrid motor neuron (NSC-34) culture treated with BSSG undergoes a dose-dependent cell loss. Surviving cells show increased expression of HSP70, decreased cytosolic heavy neurofilament expression, and have various morphological abnormalities. CD-1 mice fed mouse chow pellets containing BSSG for 15 weeks showed motor deficits and motor neuron loss in the lumbar and thoracic spinal cord, along with decreased glutamate transporter labelling, and increased ...Continue Reading

References

Nov 1, 1977·Journal of the Neurological Sciences·B E Tomlinson, D Irving
Jan 1, 1991·General Pharmacology·M NavarroP Lorenzo
Sep 1, 1989·Journal of Neurochemistry·S M RossP S Spencer
Dec 1, 1989·Journal of the Neurological Sciences·T L PerryS Hansen
Nov 7, 1980·Biochimica Et Biophysica Acta·T Kastelic-Suhadolc
Feb 1, 1995·Journal of Neurochemistry·H Jurevics, P Morell
Feb 1, 1996·Behavioral Neuroscience·R GerlaiJ Roder
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D LütjohannI Björkhem
Sep 1, 1996·Neurobiology of Learning and Memory·R Gerlai, J Roder
Jan 3, 1997·The Journal of Biological Chemistry·K Murakami-MurofushiH Murofushi
Oct 6, 1997·Neuroreport·P BarnéoudP Moser
Jul 4, 1998·The Journal of Biological Chemistry·A V TzingounisM P Kavanaugh
Mar 4, 2000·Cell Stress & Chaperones·S KunimotoK Murakami-Murofushi
Jun 1, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D J SandersP A Hepburn
Aug 6, 2000·Medical Hypotheses·S M DobbsA Charlett
Jan 17, 2002·Neurotoxicology and Teratology·C E MorrowM L Reyes
Feb 16, 2002·Journal of Neurovirology·Sareen E GalbraithS Louise Cosby
Sep 11, 2002·Cell Structure and Function·Shohko KunimotoKimiko Murakami-Murofushi
Oct 18, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Garth L NicolsonJohn Pomfret
Apr 23, 2003·Advances in Colloid and Interface Science·Britta M Folmer
Aug 28, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Tim KarlStephan von Hörsten
Dec 4, 2003·Brain Research. Developmental Brain Research·Gang QuanStephen D Turley
Dec 31, 2003·Trends in Neurosciences·Shyam D Rao, John H Weiss
Aug 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Susan J MurchSandra Anne Banack
Dec 2, 2004·Brain Research. Brain Research Reviews·Luis H BarbeitoJoseph S Beckman
Mar 26, 2005·Canadian Journal of Physiology and Pharmacology·J M B WilsonC A Shaw

❮ Previous
Next ❯

Citations

Nov 7, 2007·Neuromolecular Medicine·Christopher A Shaw, Günter U Höglinger
Jul 28, 2009·Neuroreport·Grace LeeChristopher A Shaw
Oct 22, 2011·International Journal of Environmental Research and Public Health·Alexander S ChiuBrett A Neilan
Dec 16, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Walter G Bradley, Deborah C Mash
Feb 17, 2010·Food Chemistry·Thomas E Marler, Christopher A Shaw
Jun 29, 2010·Annals of Neurology·Wei-Bin ShenPaul J Yarowsky
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Glen E KisbyPeter S Spencer
Dec 10, 2013·Experimental Gerontology·Jackalina M Van KampenDenis G Kay
Apr 14, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Li-hua JiangGang Chen
Jan 28, 2015·Progress in Lipid Research·Tim VanmierloJerome J A Hendriks
Sep 11, 2009·Journal of Inorganic Biochemistry·Christopher A Shaw, Michael S Petrik
Jun 24, 2017·Antioxidants & Redox Signaling·Maria Valeria CataniMauro Maccarrone
Oct 13, 2017·The EPMA Journal·Jackalina M Van Kampen, Harold A Robertson
Oct 17, 2018·Neural Regeneration Research·Jessica R MorriceChristopher A Shaw
Apr 23, 2020·Frontiers in Plant Science·Kassiani KytidouJohannes M F G Aerts
Jun 10, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·N ChernoffW M Winnik
Aug 28, 2020·The Journal of Experimental Biology·Birgit MichelsLudger A Wessjohann
Nov 14, 2020·The Biochemical Journal·Michio Shimamura
Jun 27, 2021·Cellular and Molecular Life Sciences : CMLS·Jannigje Rachel KokLaura Ferraiuolo
Nov 10, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Mehran ShaghaghiJenifer L Thewalt
Sep 3, 2021·Neural Regeneration Research·Bridget Martinez, Philip V Peplow
Mar 17, 2009·Toxicon : Official Journal of the International Society on Toxinology·Peter B Nunn, Malarvizhi Ponnusamy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.