Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice

PloS One
Jia-Qing ZhangBao-Song Xing

Abstract

Diquat is a bipyridyl herbicide that has been widely used as a model chemical for in vivo studies of oxidative stress due to its generation of superoxide anions, and cytotoxic effects. There is little information regarding the toxic effects of diquat on the female reproductive system, particularly ovarian function. Thus, we investigated the reproductive toxic effects of diquat on female mice. Chronic exposure to diquat reduced ovary weights, induced ovarian oxidative stress, resulted in granulosa cell apoptosis, and disrupted oocyte developmental competence, as shown by reactive oxygen species (ROS) accumulation, decreased polar body extrusion rates and increased apoptosis-related genes expression. Additionally, after diquat treatment, the numbers of fetal mice and litter sizes were significantly reduced compared to those of control mice. Thus, our results indicated that chronic exposure to diquat induced reproductive toxicity in female mice by promoting the ROS production of gruanousa cells and ooctyes, impairing follicle development, inducing apoptosis, and reducing oocyte quality. In conclusion, our findings indicate that diquat can be used as a potent and efficient chemical for in vivo studies of female reproductive toxicit...Continue Reading

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Citations

Jan 20, 2017·Current Environmental Health Reports·Brandon L Pearson, Dan Ehninger
Apr 25, 2021·Environmental Science and Pollution Research International·Ali Acar
Aug 31, 2021·Frontiers in Veterinary Science·Jiaxin ChenDayou Shi

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