Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells

Cancer Research
Amie L HolmesJohn Pierce Wise

Abstract

Hexavalent chromium [Cr(VI)] compounds are established human lung carcinogens. The carcinogenicity of Cr(VI) is related to its solubility, with the most potent carcinogens being the insoluble particulate Cr(VI) compounds. However, it remains unknown why particulate Cr(VI) is more carcinogenic than soluble Cr(VI). One possible explanation is that particulates may provide more chronic exposures to chromate over time. We found that aneuploid cells increased in a concentration- and time-dependent manner after chronic exposure to lead chromate. Specifically, a 24-hour lead chromate exposure induced no aneugenic effect, whereas a 120-hour exposure to 0.5 and 1 microg/cm2 lead chromate induced 55% and 60% aneuploid metaphases, respectively. We also found that many of these aneuploid cells were able to continue to grow and form colonies. Centrosome defects are known to induce aneuploidy; therefore, we investigated the effects of chronic lead chromate exposure on centrosomes. We found that centrosome amplification in interphase and mitotic cells increased in a concentration- and time-dependent manner with 0.5 and 1 microg/cm2 lead chromate for 120 hours, inducing aberrant centrosomes in 18% and 21% of interphase cells and 32% and 69% of...Continue Reading

References

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Feb 16, 2005·Toxicology and Applied Pharmacology·Amie L HolmesJohn Pierce Wise
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Nov 12, 2005·Molecular and Cellular Biochemistry·Sandra S WiseJohn Pierce Wise

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Citations

Dec 17, 2009·Chemical Research in Toxicology·Sandra S WiseJohn Pierce Wise
Jun 23, 2007·American Journal of Respiratory Cell and Molecular Biology·Hong XieJohn Pierce Wise
Oct 11, 2013·Particle and Fibre Toxicology·Patti C Zeidler-ErdelyJames M Antonini
Feb 15, 2011·Expert Opinion on Therapeutic Targets·Riccardo Colombo, Jürgen Moll
Feb 26, 2016·Toxicology and Applied Pharmacology·Sandra S WiseJohn Pierce Wise
Jul 31, 2012·Free Radical Biology & Medicine·Yana Chervona, Max Costa
Dec 24, 2011·Mutation Research·Sandra S Wise, John Pierce Wise
Jul 28, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Tânia Li ChenJohn Pierce Wise
Nov 26, 2008·Toxicology and Applied Pharmacology·Hong XieJohn Pierce Wise
Mar 4, 2008·Aquatic Toxicology·Britton C GoodaleJohn Pierce Wise
Mar 23, 2007·Mutation Research·Iraklis PapageorgiouCharles Patrick Case
Sep 15, 2010·Environmental and Molecular Mutagenesis·John Pierce WiseAbouEl-Makarim Aboueissa
Jul 21, 2006·Toxicology Letters·G IarmarcovaiT Orsière
Aug 22, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julieta MartinoJohn Pierce Wise
Jan 14, 2011·Cytogenetic and Genome Research·F Pacchierotti, U Eichenlaub-Ritter
May 22, 2009·Toxicology and Industrial Health·Df AlleyA Jalbert
Dec 2, 2010·Biochemical Society Transactions·Amie L Holmes, John Pierce Wise
Dec 2, 2010·Biochemical Society Transactions·Sandra S Wise, John Pierce Wise
Dec 16, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Andrew VonHandorfAlvaro Puga
Sep 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hong-Min QinSiegfried Knasmueller
Jun 23, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Idoia MeazaJohn Pierce Wise
Jul 19, 2021·Seminars in Cancer Biology·Andrew VonHandorfAlvaro Puga

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