Chronic exposure to natural uranium via drinking water affects bone in growing rats

Biochimica Et Biophysica Acta
Ndéye Marième Wade-GueyeMaâmar Souidi

Abstract

Bone is the main site of uranium accumulation after long term contamination. Several studies describe that at high dose of exposure, uranium impairs bone growth. Nevertheless little is known about the effects of chronic exposure at low doses of this radionuclide on bone, especially when ingested via drinking water, which is considered as the main exposure pathway for the public. In this study, male rats were exposed to natural uranium in drinking water for a 9 month period, either at 40 mg l(-1) starting just after birth (post-natal model) or starting at 3 months of age (adult model). In the post-natal model at 40 mg l(-1), three-dimensional microtomography analysis showed that NU decreased significantly the cortical bone diameter in NU-contaminated rats. Bone histomorphometry analysis also showed a significant increase of the osteoid thickness in trabecular bone of the femur of NU-contaminated rats. In addition, mRNA expression in trabecular bone of genes involved in osteoblast differentiation (OSX, BMP2, RUNX2), bone remodeling (TRAP, OCN), bone mineralization (BSP, OPN, DMP1), calcium transport (TRPV5) as well as vitamin D receptor (VDR) was significantly decreased in this model. In contrast, in the adult model, no morphomet...Continue Reading

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Citations

Oct 28, 2015·Metallomics : Integrated Biometal Science·Łukasz SzyrwielRyszard Lobinski
Nov 26, 2013·Metabolomics : Official Journal of the Metabolomic Society·Stéphane GrisonMaâmar Souidi
Apr 3, 2014·BioMed Research International·Isabelle DublineauJocelyne Aigueperse
Jun 1, 2017·Metallomics : Integrated Biometal Science·Sarah Ameziane-Le HirClaude Vidaud
Oct 31, 2018·Journal of Toxicology and Environmental Health. Part a·Melissa A McDiarmidPatricia Gucer
May 24, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lucile HuraultGeorges F Carle
Oct 18, 2019·Biological Trace Element Research·Shuang WangYuhui Hao
May 18, 2018·Environmental Health and Preventive Medicine·Yong-Chao YueWei He
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Xubin LuZhangping Yang

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