Chronic Exposure to Sodium Fluoride Triggers Oxidative Biochemistry Misbalance in Mice: Effects on Peripheral Blood Circulation

Oxidative Medicine and Cellular Longevity
Giza Hellen Nonato MirandaRafael Rodrigues Lima

Abstract

The excessive fluoride (F) exposure is associated with damage to cellular processes of different tissue types, due to changes in enzymatic metabolism and breakdown of redox balance. However, few studies evaluate doses of F compatible with human consumption. Thus, this study evaluated the effects of chronic exposure to sodium fluoride (NaF) on peripheral blood of mice from the evaluation of biochemical parameters. The animals were divided into three groups (n = 10) and received three concentrations of NaF in the drinking water for 60 days: 0 mg/L F, 10 mg/L F, and 50 mg/L F. The blood was then collected for trolox equivalent antioxidant capacity (TEAC), thiobarbituric acid reactive substances (TBARS), concentrations of nitric oxide (NO), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH). The results showed that doses of 10 mg/L F and 50 mg/L F were able to increase TBARS concentration and decrease NO levels and CAT activity in the blood, but there was no statistical difference for SOD levels. The 50 mg/L F group showed an increase in TEAC levels and a decrease in the GSH content when compared to the control group. In this way, oxidative changes in blood from chronic exposure to F, especially at the highes...Continue Reading

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Citations

Oct 1, 2020·Biological Trace Element Research·Victória Dos Santos ChemeloRafael Rodrigues Lima
Nov 27, 2019·Experimental Biology and Medicine·Amos O AbolajiEbenezer O Farombi
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Dinair Pamplona-SantosRafael Rodrigues Lima
May 30, 2020·International Journal of Molecular Sciences·Micaele Maria Lopes CastroRafael Rodrigues Lima
Sep 17, 2020·Brazilian Journal of Biology = Revista Brasleira De Biologia·D S Foda, S G Shams
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Agnieszka Karolina GrzegorzewskaAndrzej Sechman
May 19, 2021·Biological Trace Element Research·Linet M AngwaDianjun Sun
Aug 20, 2021·Ecotoxicology and Environmental Safety·Zhuanxu OuyangHui Zhang
Oct 15, 2021·Frontiers in Pharmacology·Leidiane Alencar de Oliveira LimaRafael Rodrigues Lima

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