Chronic exposures to low and high concentrations of ibuprofen elicit different gene response patterns in a euryhaline fish

Environmental Science and Pollution Research International
Ken M JeffriesRichard E Connon

Abstract

Ibuprofen is one of the most commonly detected pharmaceuticals in wastewater effluent; however, the effects of ibuprofen on aquatic organisms are poorly understood. This study presents the transcriptome-wide response of the inland silverside, Menidia beryllina, to chronic exposure to ibuprofen. At the lowest exposure concentration (0.0115 mg/L), we detected a downregulation of many genes involved in skeletal development, aerobic respiration, and immune function. At the highest exposure concentration (1.15 mg/L), we detected increased expression of regulatory genes in the arachidonic acid metabolism pathway and several immune genes involved in an inflammatory response. Additionally, there was differential expression of genes involved in oxidative stress responses and a downregulation of genes involved in osmoregulation. This study provides useful information for monitoring the effects of this common wastewater effluent contaminant in the environment and for the generation of biomarkers of exposure to ibuprofen that may be transferable to other fish species.

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Citations

Oct 29, 2015·Environmental Science and Pollution Research International·Miriam HampelHelmut Segner
Jul 1, 2016·Water, Air, and Soil Pollution·Ariel MarchlewiczDanuta Wojcieszyńska
Aug 5, 2016·Environmental Science and Pollution Research International·A González-MiraA Torreblanca
Jul 28, 2016·Environmental Science & Technology·Susanne M BranderDaniel Schlenk
Apr 12, 2017·International Journal of Phytoremediation·Premysl LandaTomas Vanek
Jan 25, 2017·Environmental Science and Pollution Research International·Ariel MarchlewiczDanuta Wojcieszyńska
Mar 13, 2019·Environmental Science and Pollution Research International·Efstathia NavrozidouSpyridon Ntougias
May 17, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Livier Sánchez-AcevesDamià Barceló

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