Chronic Fatigue Syndrome at Age 16 Years.

Pediatrics
Simon M CollinEsther M Crawley

Abstract

In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity. ALSPAC data were used to estimate the prevalence of chronic fatigue syndrome (CFS) at age 16 years, defined by parental report of unexplained disabling fatigue lasting ≥6 months. We investigated gender and a composite 14-item family adversity index as risk factors. School absence data were obtained from the National Pupil Database. Multiple imputation was used to address bias caused by missing data. The prevalence of CFS was 1.86% (95% confidence interval [CI]: 1.47 to 2.24). After excluding children with high levels of depressive symptoms, the prevalence was 0.60% (95% CI: 0.37 to 0.84). Authorized school absences were much higher (mean difference: 35.6 [95% CI: 26.4 to 44.9] half-day sessions per academic year) and reported depressive symptoms were much more likely (odds ratio [OR]: 11.0 [95% CI: 5.92 to 20.4]) in children with CFS than in those without CFS. Female gender (OR: 1.95 [95% CI: 1.33 to 2.86]) and family adversity (OR: 1.20 [95% CI: 1.01 to 1.42] per unit family adver...Continue Reading

Citations

Sep 23, 2016·Archives of Disease in Childhood·T NorrisE Crawley
May 5, 2017·Journal of Sleep Research·Maria PedersenHarald Hrubos-Strøm
Jan 21, 2017·Archives of Disease in Childhood·Tom NorrisEsther Crawley
Feb 1, 2018·Archives of Disease in Childhood·Simon M CollinEsther Crawley
Feb 3, 2018·Fatigue : Biomedicine, Health & Behavior·James E ClarkStuart Watson
May 3, 2019·Current Opinion in Pediatrics·Anna GregorowskiTerry Y Segal
Nov 1, 2015·Avicenna Journal of Neuropsychophysiology·Leonard A JasonKelly O'Connor
Feb 6, 2019·Frontiers in Pediatrics·Keith James Geraghty, Charles Adeniji
Aug 6, 2019·Journal of Child Health Care : for Professionals Working with Children in the Hospital and Community·Sarah S Collard, Jane Murphy

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