Chronic fatigue syndrome (CFS) symptom-based phenotypes in two clinical cohorts of adult patients in the UK and The Netherlands

Journal of Psychosomatic Research
Simon M CollinEsther Crawley

Abstract

Studies have provided evidence of heterogeneity within chronic fatigue syndrome (CFS), but few have used data from large cohorts of CFS patients or replication samples. 29 UK secondary-care CFS services recorded the presence/absence of 12 CFS-related symptoms; 8 of these symptoms were recorded by a Dutch tertiary service. Latent Class Analysis (LCA) was used to assign symptom profiles (phenotypes). Regression models were fitted with phenotype as outcome (in relation to age, sex, BMI, duration of illness) and exposure (in relation to comorbidities and patient-reported measures). Data were available for 7041 UK and 1392 Dutch patients. Almost all patients in both cohorts presented with post-exertional malaise, cognitive dysfunction and disturbed/unrefreshing sleep, and these 3 symptoms were excluded from LCA. In UK patients, six phenotypes emerged: 'full' polysymptomatic (median 8, IQR 7-9 symptoms) 32.8%; 'pain-only' (muscle/joint) 20.3%; 'sore throat/painful lymph node' 4.5%; and 'oligosymptomatic' (median 1, IQR 0-2 symptoms) 4.7%. Two 'partial' polysymptomatic phenotypes were similar to the 'full' phenotype, bar absence of dizziness/nausea/palpitations (21.4%) or sore throat/painful lymph nodes (16.3%). Women and patients wit...Continue Reading

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Citations

Jul 1, 2017·Archives of Disease in Childhood·Amberly BrigdenEsther Crawley
Dec 30, 2017·Journal of Translational Medicine·Megan E RoerinkJos W M van der Meer
Aug 3, 2019·Journal of Evaluation in Clinical Practice·Peter Denton White
Jan 8, 2018·Psychotherapy and Psychosomatics·Peter HenningsenFrancis Creed
Jul 16, 2017·BMC Health Services Research·Simon M Collin, Esther Crawley
Mar 3, 2020·Frontiers in Neurology·Michael J O Boedts
Jul 31, 2020·Journal of Translational Medicine·Eun-Jin Lim, Chang-Gue Son
Jan 23, 2019·Fatigue : Biomedicine, Health & Behavior·Ben Z KatzAndrew Lloyd
Jan 8, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Roxanne M ParslowEsther Crawley
Dec 18, 2020·BMJ : British Medical Journal·Lynne Turner-Stokes, Derick T Wade
Jan 7, 2021·Diagnostics·Rebeca Illescas-MontesJavier Ramos-Torrecillas
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Geir BjørklundJan Aaseth

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