PMID: 4326288Jul 10, 1971Paper

Chronic fenfluramine administration: some cerebral effects

British Medical Journal
S A LewisD L Dunleavy

Abstract

Human cerebral function was monitored electrophysiologically during sleep over a period of months before, during, and after the intake of fenfluramine, 40-120 mg/day. Effects included dose-related reduction of paradoxical sleep, increase of intra-sleep restlessness, and changes in E.E.G. slow-wave sleep. It is hypothesized that weight loss may be associated with increase of the last. Grinding of teeth (bruxism) also was noted.Long-term studies make it possible to demonstrate changing central effects with time, including tolerance phenomena. Withdrawal abnormalities are related to the time taken for the drug to be eliminated-in the present case reaching a maximum four days after withdrawal.

References

May 1, 1966·Electroencephalography and Clinical Neurophysiology·W Dement, S Greenberg
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Apr 1, 1970·Electroencephalography and Clinical Neurophysiology·S A LewisS L Tompsett
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Oct 1, 1964·Electroencephalography and Clinical Neurophysiology·R L WILLIAMSW B WEBB

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Citations

Aug 22, 1973·Psychopharmacologia·S R Allen, I Oswald
Aug 1, 1973·European Journal of Clinical Pharmacology·I PerssonT Deckert
Dec 19, 1977·Psychopharmacology·V BrezinováJ Thomson
Jan 1, 1991·Psychopharmacology·M WiegandJ C Krieg
Mar 1, 1974·Electroencephalography and Clinical Neurophysiology·D L DunleavyJ A Strong
Jan 1, 1973·Pharmacology, Biochemistry, and Behavior·A J ZolovickP J Morgane
Jan 1, 1986·Progress in Neurobiology·N E Rowland, J Carlton
Nov 1, 1982·Biological Psychology·C M Shapiro
Apr 16, 1998·The Journal of Emergency Medicine·L E ViveroR F Clark
Feb 1, 1976·British Journal of Clinical Pharmacology·I Oswald, V Bĕxinová
Jan 8, 1977·British Medical Journal·A MullenB P Wilson
Jul 10, 1971·British Medical Journal·I OswaldM Briggs
Jul 1, 1972·British Medical Journal·J M Steel, M Briggs
May 20, 1972·British Medical Journal
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Plamen D Penev
Jun 12, 1978·Annals of the New York Academy of Sciences·R B Messing
Jan 1, 1988·Journal of Child Psychology and Psychiatry, and Allied Disciplines·M Campbell
Jan 1, 1976·Postgraduate Medical Journal·I Oswald
Oct 1, 1980·British Journal of Clinical Pharmacology·I Oswald
Jul 1, 1996·Clinical Endocrinology·T H SchürmeyerA von zur Mühlen

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