Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke

Journal of Neuroscience Research
Wen-Lei LiDong Ya Zhu

Abstract

Cognitive deficits, including spatial memory impairment, are very common after ischemic stroke. Neurogenesis in the dentate gyrus (DG) contributes to forming spatial memory in the ischemic brain. Fluoxetine, a selective serotonin reuptake inhibitor, can enhance neurogenesis in the hippocampus in physiological situations and some neurological diseases. However, whether it has effects on ischemia-induced spatial cognitive impairment and hippocampal neurogenesis has not been determined. Here we report that fluoxetine treatment (10 mg kg(-1), i.p.) for 4 weeks promoted the survival of newborn cells in the ischemic hippocampus and, consequently, attenuated spatial memory impairment of mice after focal cerebral ischemia. Disrupting hippocampal neurogenesis blocked the beneficial effect of fluoxetine on ischemia-induced spatial cognitive impairment. These results suggest that chronic fluoxetine treatment benefits spatial cognitive function recovery following ischemic insult, and the improved cognitive function is associated with enhanced newborn cell survival in the hippocampus. Our results raise the possibility that fluoxetine can be used as a drug to treat poststroke spatial cognitive deficits.

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Dec 19, 1994·The American Journal of Medicine·C L DeVane
Aug 26, 1998·Journal of Neurobiology·F H GageJ Ray
Nov 11, 1998·Depression and Anxiety·R G Robinson
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·K JinD A Greenberg
Apr 25, 2001·Journal of Neuroscience Research·W KlapperM P Mattson
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·C S KidwellJ L Saver
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ken-ichiro TakasawaMasayasu Matsumoto
Jun 5, 2003·International Journal of Psychiatry in Medicine·Stefanie A HorsfieldStephen I Deutsch
Jun 19, 2003·The Journal of Clinical Investigation·Yunjuan SunDavid A Greenberg
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica E Malberg, Ronald S Duman
Nov 5, 2003·Annals of Neurology·Matthias EndresUlrich Laufs
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elodie DrapeauDjoher Nora Abrous
Dec 4, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Omar M E Abdel-SalamMahmoud S Arbid
Mar 3, 2004·Annals of Neurology·Jacob RaberJialing Liu
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ettore TiraboschiMaurizio Popoli
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dong Ya ZhuYou Ming Lu
Nov 16, 2004·Journal of Neurosurgery·Kudret TüreyenRobert J Dempsey
Jan 22, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Claire L GibsonSean P Murphy
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mikko SairanenEero Castrén
May 3, 2005·Brain Research·Victoria Windle, Dale Corbett
May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Olof BendelGabriel von Euler
Jun 22, 2005·Journal of Pharmacological Sciences·Keiko Mizuno, Karl Peter Giese
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg

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Citations

Oct 13, 2009·Current Neurology and Neuroscience Reports·Steven L Small, Daniel A Llano
Dec 25, 2012·Current Neurology and Neuroscience Reports·F CholletJ Pariente
Oct 17, 2013·Archives of Pharmacal Research·Hyun-Jung KimSun-Young Kong
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Koji OhiraTsuyoshi Miyakawa
Jul 31, 2012·Brain : a Journal of Neurology·Lisa BarkasWilliam P Gray
Nov 23, 2013·BMC Complementary and Alternative Medicine·Mi Deok SongJae Hwan Lew
Jul 29, 2010·Expert Review of Neurotherapeutics·Megan M Burns, David A Greenberg
Dec 23, 2015·Expert Review of Neurotherapeutics·Antje Schmidt, Jens Minnerup
Aug 6, 2009·Expert Opinion on Biological Therapy·Ronen R Leker
Nov 12, 2015·Journal of Receptor and Signal Transduction Research·Rajeev Taliyan, Sruthi Ramagiri
Jan 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi-Tao HeYi Guo
Nov 17, 2009·Behavioural Brain Research·Maha ElBeltagyPeter M Wigmore
Oct 11, 2015·Journal of Ethnopharmacology·Jee Hyun YiDong Hyun Kim
Oct 19, 2011·Journal of Neuroscience Research·R M Weffort de OliveiraE A Del Bel
Nov 22, 2011·Journal of the American Geriatrics Society·Neelima KumarAsit Baran Shil
Dec 3, 2014·Annals of Physical and Rehabilitation Medicine·F CholletI Loubinoux
Sep 15, 2015·Journal of Neuroscience Methods·Nitish MittalTimothy Schallert
Jul 29, 2015·CNS Neuroscience & Therapeutics·Li-Chao YangXiao-Liang Wang
Aug 17, 2014·The International Journal of Biochemistry & Cell Biology·Tobias D Merson, James A Bourne
May 26, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyung-Yoon KamSung Goo Kang
May 10, 2015·Behavioural Brain Research·Brendan B McAllisterRichard H Dyck
Nov 16, 2014·Current Treatment Options in Cardiovascular Medicine·Tomoko Kitago, Randolph S Marshall
May 11, 2016·Molecular Brain·Yujie DongWeidong Li
Aug 9, 2016·Bulletin of Experimental Biology and Medicine·M Yu KhodanovichM B Plotnikov
Sep 14, 2016·Journal of Chemical Neuroanatomy·Jariya Umka WelbatPeter Wigmore
Jul 2, 2016·Neurorehabilitation and Neural Repair·Walter Swardfager, Bradley J MacIntosh
Jan 6, 2018·International Journal of Molecular Sciences·Marina KhodanovichVasily Yarnykh
Feb 21, 2018·Journal of Psychopharmacology·Subhi Marwari, Gavin S Dawe
Dec 6, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Faranak Vahid-Ansari, Paul R Albert

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