Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Ying QuStanley I Rapoport

Abstract

Serotonergic 5-HT(2A/2C) receptors can be coupled to phospholipase A(2) (PLA(2)) activation to release the second messenger, arachidonic acid (AA), from membrane phospholipids. We wished to see if this signaling process in rat brain would be altered by chronic administration followed by 3days of washout of the selective serotonin reuptake inhibitor, fluoxetine. We injected [(3)H]AA intravenously in unanesthetized rats and used quantitative autoradiography to determine the incorporation coefficient k() for AA (regional brain radioactivity/integrated plasma radioactivity), a marker of PLA(2) activation, in each of 86 brain regions. k() was measured following acute i.p. saline or (+/-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI, 1.0mg/kg i.p.), a 5-HT(2A/2C) receptor agonist, in rats injected for 21days with 10mg/kg i.p. fluoxetine or saline daily, followed by 3days without injection. Acute DOI produced statistically significant increments in k() in brain regions with high densities of 5-HT(2A/2C) receptors, but the increments did not differ significantly between the chronic fluoxetine- and saline-treated rats. Additionally, chronic fluoxetine compared with saline widely and significantly increased baseline values of k(). Thes...Continue Reading

References

Aug 15, 1995·European Journal of Pharmacology·N TilakaratneE Friedman
Jul 1, 1994·Trends in Pharmacological Sciences·P Blier, C de Montigny
Oct 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M el MansariP Blier
Dec 20, 1996·Neuroscience Letters·M C ChangS I Rapoport
Jun 25, 1998·Journal of Child and Adolescent Psychopharmacology·F S GoD R Rosenberg
Aug 26, 1998·The Journal of Clinical Psychiatry·H L BoerlinC L Hammen
Dec 24, 1998·Journal of Clinical Psychopharmacology·J D AmsterdamC Beasley
Feb 3, 1999·Annals of the New York Academy of Sciences·K A BergW P Clarke
Feb 11, 1999·Neurochemical Research·L Sokoloff
Mar 19, 1999·Journal of Neuroscience Research·N K NgP T Wong
Aug 5, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G K Aghajanian, G J Marek
Oct 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J R CalabreseM D Shelton
Apr 12, 2000·Brain Research Bulletin·T Xu, S C Pandey
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S T Szabo, P Blier
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie G Hensler
Jul 2, 2002·Archives of General Psychiatry·Stanley I Rapoport, Francesca Bosetti
Feb 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ying QuStanley I Rapoport

❮ Previous
Next ❯

Citations

Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Sep 1, 2007·Behavioural Pharmacology·Jessica A Valluzzi, KinHo Chan
Feb 4, 2003·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Leslie London
Feb 18, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Epolia RamadanMireille Basselin
Dec 20, 2011·Brain Research Bulletin·Mireille BasselinStanley I Rapoport
Jul 27, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Robert K McNamaraRonald Jandacek
Aug 4, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Zhi-Xin Yuan, Stanley I Rapoport
Aug 31, 2010·The International Journal of Neuropsychopharmacology·Borja García-BuenoJuan C Leza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.