Chronic folate deficiency induces glucose and lipid metabolism disorders and subsequent cognitive dysfunction in mice

PloS One
Mei ZhaoDe-Xiang Xu

Abstract

Previous studies have shown that folate levels were decreased in patients with type 2 diabetes (T2D) and further lowered in T2D patients with cognitive impairment. However, whether folate deficiency could cause T2D and subsequent cognitive dysfunction is still unknown. The present study aimed to explore the effects of chronic folate deficiency (CFD) on glucose and lipid metabolism and cognitive function in mice. Seven-week-old mice were fed with either a CFD or control diet for 25 weeks. Serum folate was significantly reduced, whereas serum total homocysteine was significantly increased in the CFD group. Moreover, CFD induced obesity after a 6-week diet treatment, glucose intolerance and insulin resistance after a 16-week-diet treatment. In addition, CFD reduced the hepatic p-Akt/Akt ratio in response to acute insulin administration. Moreover, CFD increased serum triglyceride levels, upregulated hepatic Acc1 and Fasn mRNA expression, and downregulated hepatic Cd36 and ApoB mRNA expression. After a 24-week diet treatment, CFD induced anxiety-related activities and impairment of spatial learning and memory performance. This study demonstrates that folate deficiency could induce obesity, glucose and lipid metabolism disorders and ...Continue Reading

References

Oct 7, 2004·The Journal of Biological Chemistry·Kazuhiko NamekataHideo Kimura
Jul 14, 2006·Neurobiology of Aging·Alexandra BernardoMichael P McDonald
Jul 27, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Anthony S Wierzbicki
Jun 13, 2008·Nature Protocols·Thomas D Schmittgen, Kenneth J Livak
Jan 24, 2009·Lab Animal·Yaron DekelRimona Margalit
Jun 13, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Yang ZhaoDennis E Vance
Jan 7, 2011·American Journal of Physiology. Renal Physiology·Xiaoxin X WangMoshe Levi
Jun 24, 2011·The Journal of Nutrition·Tina W ChewMarie A Caudill
Aug 25, 2011·Current Pharmaceutical Design·Anna Maria SironiAmalia Gastaldelli
Jun 21, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nassila AkchicheJean-Luc Daval
Jan 30, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Scott RectorJamal A Ibdah
Apr 29, 2014·Metabolic Brain Disease·Helle M Sickmann, Helle S Waagepetersen
Aug 29, 2014·The Lancet. Diabetes & Endocrinology·Stefan L C GeijselaersGeert Jan Biessels
May 6, 2015·Ageing Research Reviews·João Ricardo AraújoElisa Keating
Sep 30, 2015·The Journal of Clinical Endocrinology and Metabolism·Emma NilssonCharlotte Ling
Jul 9, 2016·Canadian Journal of Physiology and Pharmacology·Dragan HrncicOlivera Stanojlovic
Oct 18, 2016·The Indian Journal of Medical Research·Muthuvel BharathselviKonerirajapuram N Sulochana
Jan 14, 2017·Molecular and Cellular Endocrinology·Dan WangDian-Wu Liu
Apr 25, 2017·Diabetes Research and Clinical Practice·K OgurtsovaL E Makaroff
May 17, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Priya PaltaSherita Hill Golden
Jun 27, 2017·Frontiers in Cellular Neuroscience·Susan HelmAhmad Salehi
Jul 13, 2017·Physiology & Behavior·Lin FuDe-Xiang Xu

❮ Previous
Next ❯

Citations

Jun 2, 2020·World Journal of Gastroenterology : WJG·Feng-Zhi XinJian-Gao Fan
Jan 1, 2021·Frontiers in Molecular Biosciences·Xinyun GuAhmad Aljada
May 29, 2021·Frontiers in Endocrinology·Hannah MaudeInês Cebola
Aug 30, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rui ZhaoLihong Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
fatty acid assay
X-ray

Software Mentioned

LightCycler 480
NIH Scion Image Program
NIH Image J
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.