PMID: 9191075Jun 1, 1997Paper

Chronic food restriction and streptozotocin-induced diabetes differentially alter prodynorphin mRNA levels in rat brain regions

Brain Research. Molecular Brain Research
Y BermanK D Carr

Abstract

It was previously reported that chronic food restriction and streptozotocin-induced diabetes lead to brain region-specific changes in levels of Prodyn-derived peptides. These changes parallel behavioral adaptations that are reversed by opioid antagonists. In the present study, effects of food restriction and diabetes on Prodyn gene expression were measured in rat brain regions using a quantitative solution hybridization mRNA assay. Picogram amounts of Prodyn mRNA were determined in extracts of five brain regions. The highest density of Prodyn mRNA was observed in extracts of nucleus accumbens (4.68 pg/microg total RNA), bed nucleus of the stria terminalis (4.18 pg/microg), and in caudate nucleus (3.51 pg/microg). Lower levels were observed in the lateral hypothalamus (1.87 pg/microg) and central nucleus of the amygdala (1.22 pg/microg). Food restriction and diabetes both markedly increased the levels of Prodyn mRNA in the central amygdala (163% and 93%, respectively). Levels in the lateral hypothalamus were also increased (35% and 29%, respectively), though only the food-restriction effect was statistically significant. Neither treatment altered prodynorphin mRNA levels in the caudate nucleus, nucleus accumbens or bed nucleus o...Continue Reading

References

Mar 1, 1976·The Journal of Comparative Neurology·R Norgren
Nov 1, 1992·Brain Research. Molecular Brain Research·L ThaiJ S Hong
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A C CatoP Herrlich
Nov 26, 1990·Brain Research·A S LevineP S Portoghese
Apr 1, 1990·The American Journal of Physiology·M A Della-FeraJ A Paterson
Jun 1, 1985·Brain Research Bulletin·J E MorleyD D Krahn
Mar 26, 1986·Brain Research·B A GosnellA S Levine
Jul 15, 1986·The Journal of Comparative Neurology·J H Fallon, F M Leslie
Jan 1, 1988·Molecular Neurobiology·R E Harlan
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·O CivelliE Herbert
Apr 1, 1985·The American Journal of Physiology·T R KasserR J Martin
Jun 30, 1970·Brain Research·R Norgren
Jan 7, 1983·Science·R PrzewłockiL D Reid
Nov 1, 1983·Peptides·J E Morley, A S Levine
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Oct 1, 1993·Frontiers in Neuroendocrinology·M F DallmanM Smith
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·T G DoyleB A Gosnell

❮ Previous
Next ❯

Citations

Jan 8, 1999·Peptides·G A OlsonA J Kastin
Nov 23, 2005·Behavioral Neuroscience·Mary M BoggianoPamela K Wauford
Oct 14, 2009·Molecular and Cellular Endocrinology·A Sainsbury, L Zhang
Feb 27, 2010·Alcoholism, Clinical and Experimental Research·Guo-Qing ChangSarah F Leibowitz
Sep 27, 2005·Journal of Ethnopharmacology·Hongmeng XuKazuo Hanaoka
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert M SilvaRichard J Bodnar
Oct 20, 2000·The Journal of Biological Chemistry·Y BermanL A Devi
Apr 26, 2007·Molecular Endocrinology·Amanda SainsburyHerbert Herzog
May 2, 2018·Frontiers in Endocrinology·Monika DudekJoanna H Sliwowska
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael J GlassAllen S Levine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.