Chronic gamma radiation resistance in fungi correlates with resistance to chromium and elevated temperatures, but not with resistance to acute irradiation

Scientific Reports
Igor ShuryakM J Daly

Abstract

Exposure to chronic ionizing radiation (CIR) from nuclear power plant accidents, acts of terrorism, and space exploration poses serious threats to humans. Fungi are a group of highly radiation-resistant eukaryotes, and an understanding of fungal CIR resistance mechanisms holds the prospect of protecting humans. We compared the abilities of 95 wild-type yeast and dimorphic fungal isolates, representing diverse Ascomycota and Basidiomycota, to resist exposure to five environmentally-relevant stressors: CIR (long-duration growth under 36 Gy/h) and acute (10 kGy/h) ionizing radiation (IR), heavy metals (chromium, mercury), elevated temperature (up to 50 °C), and low pH (2.3). To quantify associations between resistances to CIR and these other stressors, we used correlation analysis, logistic regression with multi-model inference, and customized machine learning. The results suggest that resistance to acute IR in fungi is not strongly correlated with the ability of a given fungal isolate to grow under CIR. Instead, the strongest predictors of CIR resistance in fungi were resistance to chromium (III) and to elevated temperature. These results suggest fundamental differences between the mechanisms of resistance to chronic and acute ra...Continue Reading

References

May 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K W Minton, M J Daly
Oct 28, 2004·Mycological Research·Nelli N ZhdanovaPatrick McDermott
Mar 22, 2007·PLoS Biology·Michael J DalyJames K Fredrickson
Feb 15, 2008·The ISME Journal·James K FredricksonMichael J Daly
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eugene Gladyshev, Matthew Meselson
Oct 14, 2008·Current Opinion in Microbiology·Ekaterina Dadachova, Arturo Casadevall
Jan 28, 2009·Nature Reviews. Microbiology·Michael J Daly
Aug 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rebecca L McNaughtonBrian M Hoffman
Sep 10, 2010·Journal of Biosciences·Harinder SinghShree Kumar Apte
Sep 15, 2010·PloS One·Michael J DalyRodney L Levine
Feb 1, 2011·Journal of Bacteriology·Courtney K RobinsonJocelyne Diruggiero
Mar 5, 2011·Microbiology and Molecular Biology Reviews : MMBR·Dea Slade, Miroslav Radman
Dec 20, 2012·Antioxidants & Redox Signaling·Valeria C Culotta, Michael J Daly
Jan 23, 2013·Microbial Biotechnology·Jonathan A CrayJohn E Hallsworth
Mar 28, 2013·Extremophiles : Life Under Extreme Conditions·Kimberly M WebbJocelyne DiRuggiero
Dec 20, 2013·The Journal of Experimental Biology·Alistair J P BrownMichelle D Leach
Apr 15, 2014·The Journal of Nutritional Biochemistry·Nolan J HoffmanJeffrey S Elmendorf
Jun 25, 2014·Annals of Agricultural and Environmental Medicine : AAEM·Sławomir LewickiMariusz Goniewicz
May 30, 2015·The ISME Journal·Emilie ChapelleJos M Raaijmakers
Jun 14, 2015·Annual Review of Microbiology·James A Imlay
Dec 20, 2015·Journal of Bioscience and Bioengineering·Liman GaoGuiyan Liu
Aug 9, 2016·PloS One·Paridhi GuptaRadha K Maheshwari
Sep 21, 2016·Fungal Biology·Aline Cristina VelhoMarciel J Stadnik
Apr 15, 2017·Applied Microbiology and Biotechnology·Ningzi GuanLong Liu
Aug 5, 2017·Standards in Genomic Sciences·Vera Y MatrosovaMichael J Daly
Oct 19, 2017·Proceedings of the National Academy of Sciences of the United States of America·Ajay SharmaMichael J Daly
Oct 12, 2018·Environmental Microbiology·James A Imlay

❮ Previous
Next ❯

Software Mentioned

lme4 R
pROC
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.