Chronic ghrelin administration restores hippocampal long-term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease

Hippocampus
Maryam EslamiFatemeh Goshadrou

Abstract

Alzheimer's disease (AD), as a common age-related dementia, is a progressive manifestation of cognitive decline following synaptic failure resulted majorly by senile plaques composed of deposits of amyloid beta (Aβ). Ghrelin is a multifunctional peptide hormone with receptors present in various brain tissues including hippocampus and has been associated with neuroprotection, neuromodulation, and memory processing. Here, we investigated the neuroprotective and therapeutic effects of intracerebroventricular (icv) ghrelin infusion for 2 weeks on passive avoidance learning (PAL), memory retention, and synaptic plasticity in the hippocampal dentate gyrus (DG) and CA1 of both normal rats and Aβ1-42-induced neurotoxicity in AD model. Male Wistar rats were evaluated for their passive memory performance using a shuttle box while some groups had already received Aβ1-42 and/or chronic ghrelin. Using field potential recording, the induction of short- and long-term potentiation (STP and LTP) was studied in DG granule cells along with the LTP changes in CA1 pyramidal neurons through stimulation of the medial perforant path (mPP) and Schaffer collaterals (SCs), respectively. Our results demonstrated that chronic ghrelin treatment not only imp...Continue Reading

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Citations

Nov 27, 2018·The Journal of Endocrinology·Lenka MaletínskáJaroslav Kuneš
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Maria LucaAntonina Luca
Jan 31, 2020·Frontiers in Neurology·Liyuan FanYuming Xu
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Jan 1, 2021·Frontiers in Neuroscience·Niklas Reich, Christian Hölscher
Apr 4, 2021·Behavioural Brain Research·Siamak Beheshti, Hadi Dehestani
Jun 9, 2021·Neural Regeneration Research·Xin HeYi-Xue Xue
Jun 26, 2021·World Journal of Diabetes·Milagros RojasValmore Bermúdez
Oct 21, 2020·Current Pharmaceutical Design·Mami NodaJiangang Long

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