Chronic Glibenclamide Treatment Attenuates Walker-256 Tumour Growth in Prediabetic Obese Rats

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Claudinéia Conationi da Silva FrancoPaulo Cezar de Freitas Mathias

Abstract

The sulphonylurea glibenclamide (Gli) is widely used in the treatment of type 2 diabetes. In addition to its antidiabetic effects, low incidences of certain types of cancer have been observed in Gli-treated diabetic patients. However, the mechanisms underlying this observation remain unclear. The aim of the present work was to evaluate whether obese adult rats that were chronically treated with an antidiabetic drug, glibenclamide, exhibit resistance to rodent breast carcinoma growth. Neonatal rats were treated with monosodium L-glutamate (MSG) to induce prediabetes. Control and MSG groups were treated with Gli (2 mg/kg body weight/day) from weaning to 100 days old. After Gli treatment, the control and MSG rats were grafted with Walker-256 tumour cells. After 14 days, grafted rats were euthanized, and tumour weight as well as glucose homeostasis were evaluated. Treatment with Gli normalized tissue insulin sensitivity and glucose tolerance, suppressed fasting hyperinsulinaemia, reduced fat tissue accretion in MSG rats, and attenuated tumour growth by 27% in control and MSG rats. Gli treatment also resulted in a large reduction in the number of PCNA-positive tumour cells. Although treatment did improve the metabolism of pre-diabet...Continue Reading

Citations

Jun 19, 2019·The Journal of Physiology·Veridiana Mota MoreiraPaulo Cezar de Freitas Mathias
Nov 1, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Débora Luiza QuintilhanoGisele Lopes Bertolini
Oct 20, 2020·Experimental Physiology·Carina PreviateClaudinéia Conationi da Silva Franco
May 27, 2021·Environmental Toxicology·Mengyuan LiFeifei Feng

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