PMID: 15239404Jul 9, 2004Paper

Chronic graft-versus-host disease of the liver presenting as an acute hepatitis following nonmyeloablative hematopoietic stem cell transplantation

International Journal of Hematology
Hoyoung MaengYoo Hong Min

Abstract

Chronic graft-versus-host disease (GVHD) of the liver usually presents as an indolent cholestatic disease. We observed 3 patients in whom chronic GVHD of the liver after allogeneic nonmyeloablative hematopoietic stem cell transplantation (HSCT) presented with marked elevations of serum aminotransferases, clinically resembling acute viral hepatitis. The liver biopsies revealed predominant diffuse lobular injury and degenerative small bile ducts. Prompt administration of high-dose immunosuppressive therapy achieved a rapid improvement of liver enzymes and bilirubin levels. We conclude that a distinct syndrome of chronic hepatic GVHD presenting as an acute hepatitis should be considered as one possible explanation for hepatic dysfunction in patients who receive nonmyeloablative allogeneic HSCT.

References

May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H M ShulmanG B McDonald
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S I StrasserG B McDonald
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Apr 19, 2003·Journal of Clinical Gastroenterology·Osman OzdoğanNurdan Tözün

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Citations

Sep 17, 2013·International Journal of Hematology·Takayoshi TachibanaShin Fujisawa
Aug 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kiran Upadhyay, Richard N Fine
Jun 29, 2016·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·R-G Mihăilă
Oct 27, 2006·Pediatric Blood & Cancer·Héctor Melín-AldanaDavid A Jacobsohn
Dec 2, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ashley E StueckM Isabel Fiel

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