PMID: 7333866Jan 1, 1981Paper

Chronic granulomatous disease: effect of sulfamethoxazole/trimethoprim on neutrophil microbicidal function

Helvetica paediatrica acta
R A SegerF K Gmünder

Abstract

Normal and chronic granulomatous disease (CGD) neutrophils accumulated sulfamethoxazole (SMX) 3-fold and trimethoprim (TMP) 14-fold, possibly through a non-ionic diffusion and pH-partition mechanism. CGD neutrophils incubated with SMX/TMP after phagocytosis of S. aureus killed the bacteria. These findings explain the clinically observed beneficial effect of SMX/TMP in the treatment of infections in CGD and in other conditions characterized by impaired phagocyte microbicidal capacity.

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