Chronic GVHD: Where are we? Where do we want to be? Will immunomodulatory drugs help?

Bone Marrow Transplantation
Y P L LinharesRobert Peter Gale

Abstract

Chronic GVHD (cGVHD) is an important problem after allotransplants. Some risk factors for cGVHD are similar to those of acute GVHD (aGVHD) but others are distinct indicating sometimes overlapping but unique pathogeneses. Precise incidence and prevalence data of cGVHD are lacking because of diverse diagnostic criteria but a 50% risk is a reasonable estimate. Incidence and prevalence of cGVHD are probably growing because of increased use of unrelated donors, blood rather than bone marrow (BM) grafts, decreased early transplant-related mortality (TRM) and increasing frequency of allotransplants. Pathophysiology of cGVHD is complex and poorly understood. Notably, no reliable surrogate end point to predict mechanism(s) of cGVHD has been identified. Therapy of cGVHD is unsatisfactory. Corticosteroids are effective but other drugs are controversial and few are rigorously tested in randomized trials. Highly variable response rates are reported because of small sample sizes and inconsistencies in eligibility, diagnostic and response criteria. We focus on the possible role of immunomodulatory drugs (IMiDs), thalidomide lenalidomide and pomalidomide, in preventing and treating cGVHD. The data suggest activity of thalidomide but at doses n...Continue Reading

References

Apr 1, 1979·The American Journal of Medicine·P R Graze, R P Gale
Apr 16, 1992·The New England Journal of Medicine·G B VogelsangJ R Wingard
May 1, 1991·British Journal of Haematology·D HeneyD L Barnard
Mar 1, 1995·Leukemia & Lymphoma·V BarakA Nagler
Nov 18, 2000·Bone Marrow Transplantation·P V BrowneH Enright
Jun 13, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·M AroraD F Weisdorf
Jan 23, 2002·Bone Marrow Transplantation·M TrendelenburgA Gratwohl
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith DredgeAngus G Dalgleish
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Peter H SchaferDavid I Stirling
Apr 30, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeMary E D Flowers
Jun 19, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stephanie J LeeJane C Weeks
Aug 15, 2003·Leukemia & Lymphoma·Mary E D Flowers, Paul J Martin
Aug 21, 2003·Acta Dermato-venereologica·Delphine Staumont-SalléBenoit Catteau
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Vikas Bhushan, Robert H Collins
Jul 14, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A ScheyA G Dalgleish
Jul 28, 2005·Blood·Steven Z PavleticUNKNOWN National Heart, Lung, and Blood Institute Unrelated Donor Marrow Transplantation Trial
Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Howard M ShulmanGeorgia B Vogelsang
Jan 24, 2006·Blood Reviews·Mitchell E Horwitz, Keith M Sullivan
Jan 31, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kirk R SchultzSteven Z Pavletic
Mar 1, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Steven Z PavleticUNKNOWN Response Criteria Working Group
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paul J MartinUNKNOWN Design of Clinical Trials Working Group
Oct 21, 2006·Current Opinion in Hematology·Kristin Baird, Steven Z Pavletic
Oct 24, 2006·Bone Marrow Transplantation·N T Le, N Chao
Jan 16, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Warren D ShlomchikSteven Z Pavletic
Apr 18, 2007·Nature Reviews. Immunology·Warren D Shlomchik
Aug 7, 2007·Nature Immunology·Anne BrüstleMichael Lohoff
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi ZhangStephen G Emerson
Oct 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefanie SarantopoulosJerome Ritz
Mar 18, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Waye Chu, Ronald E Gress

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Citations

Apr 14, 2015·Expert Opinion on Biological Therapy·Moreno FestucciaBenedetto Bruno
Jun 6, 2014·Cancer Investigation·Karim ArnaoutImad A Tabbara
Dec 15, 2015·Bone Marrow Transplantation·I PusicS Z Pavletic
May 6, 2015·The Journal of Investigative Dermatology·Florence MorinFrédéric Batteux
Feb 25, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Binsheng WangHe Huang
Oct 9, 2014·Immunological Investigations·Youssef Mohamed Mosaad
Jun 28, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Matthias GrubeDaniel Wolff
Oct 25, 2016·The Journal of Investigative Dermatology·Florence MorinFrédéric Batteux
Jun 20, 2017·Advanced Drug Delivery Reviews·Rose DiLoretoIwijn De Vlaminck
Feb 21, 2018·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Hadeel R BakhshShahrukh K Hashmi
Oct 24, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Man ZhangJonathan M Rubin
Aug 8, 2017·Bone Marrow Transplantation·J MohammedS K Hashmi
Mar 6, 2015·Archives of Disease in Childhood·Maggie AtkinsonLisa Davis
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shi-Meng JiSheng-Li Xue
Feb 19, 2021·Blood·Aleksandr Lazaryan
Dec 22, 2020·Archives of Physical Medicine and Rehabilitation·Paula Molés-PovedaEdward W Cowen

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