Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
D CentonzeP Calabresi

Abstract

Reduced glutamate-mediated synaptic transmission has been implicated in the pathophysiology of schizophrenia. Because antipsychotic agents might exert their beneficial effects against schizophrenic symptoms by strengthening excitatory transmission in critical dopaminoceptive brain areas, in the present study we have studied the effects of acute and chronic haloperidol treatment on striatal synaptic plasticity. Repetitive stimulation of corticostriatal terminals in slices induced either long-term depression or long-term potentiation (LTP) of excitatory transmission in control rats, whereas it invariably induced NMDA receptor-dependent LTP in animals treated chronically with haloperidol. Haloperidol effects were mimicked and occluded in mice lacking both D2L and D2S isoforms of dopamine D2 receptors (D2R-/-), in mice lacking D2L receptors and expressing normal levels of D2S receptors (D2R-/-;D2L-/-), and in mice lacking D2L receptors and overexpressing D2S receptors (D2L-/-). These data indicate that the blockade of D2L receptors was responsible for the LTP-favoring action of haloperidol in the striatum. In contrast, overexpression of D2S receptors uncovered a facilitatory role of this receptor isoform in LTP formation because LT...Continue Reading

Citations

Jul 8, 2005·Psychopharmacology·Christopher J MacDonald, Warren H Meck
Feb 9, 2006·Journal of Neural Transmission·G Ceresoli-BorroniR Schwarcz
Aug 2, 2012·Amino Acids·Francesco ErricoAlessandro Usiello
Oct 5, 2007·Nature Clinical Practice. Neurology·Diego CentonzeGiacomo Koch
Sep 16, 2008·Schizophrenia Bulletin·Michael J Frank
Nov 18, 2008·Schizophrenia Bulletin·Hiroki IshiguroTadao Arinami
Jan 22, 2009·Schizophrenia Bulletin·Klaas E StephanChris D Frith
Apr 13, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J FrankScott J Sherman
Jan 1, 2009·Reviews in the Neurosciences·Francesco ErricoAlessandro Usiello
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mazen A KheirbekXiaoxi Zhuang
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alessandro BertolinoWolfgang Sadee
Feb 22, 2014·Cognitive, Affective & Behavioral Neuroscience·Catherine InselEdward E Smith
Oct 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J FrankKent E Hutchison
Oct 28, 2008·Behavioural Brain Research·Michael X Cohen, Michael J Frank
Nov 24, 2007·Molecular and Cellular Neurosciences·Francesco ErricoAlessandro Usiello
Aug 7, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·James T TeoKailash Bhatia
Apr 15, 2015·Journal of Pharmaceutical and Biomedical Analysis·Francesco ErricoAlessandro Usiello
Aug 11, 2006·Journal of Neuroscience Methods·Roy M SmealKaren S Wilcox
Aug 23, 2005·Neuropharmacology·Larissa MoutsimilliEleni T Tzavara
Jan 24, 2006·Biological Psychiatry·Klaas E StephanKarl J Friston
May 14, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rae PriceTarek K Rajji
Apr 24, 2016·Schizophrenia Bulletin·Jenna M ReinenDaphna Shohamy
Nov 19, 2011·The International Journal of Neuropsychopharmacology·Tomek J Banasikowski, Richard J Beninger
Feb 25, 2006·Schizophrenia Research·Steven SilversteinVaughan Carr
Sep 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luke E SebelD James Surmeier
Mar 26, 2008·Synapse·Kristoffer SahlholmPeter Arhem
Mar 10, 2016·Harvard Review of Psychiatry·Emily M OwensCarrie E Bearden
Mar 1, 2018·Frontiers in Integrative Neuroscience·Jeff A Beeler, Devry Mourra

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