PMID: 11332550May 3, 2001Paper

Chronic health risks from aggregate exposures to ionizing radiation and chemicals: scientific basis for an assessment framework

Risk Analysis : an Official Publication of the Society for Risk Analysis
W C Chen, T E McKone

Abstract

Very little quantitative analysis is currently available on the cumulative effects of exposure to multiple hazardous agents that have either similar or different mechanisms of action. Over the past several years, efforts have been made to develop the methodologies for risk assessment of chemical mixtures, but mixed exposures to two or more dissimilar agents such as radiation and one or more chemical agents have not yet been addressed in any substantive way. This article reviews the current understanding of the health risks arising from mixed exposures to ionizing radiation and specific chemicals. Specifically discussed is how mixed radiation/chemical exposures, when evaluated in aggregation, were linked to chronic health endpoints such as cancer and intermediate health outcomes such as chromosomal aberrations. Also considered is the extent to which the current practices are consistent with the scientific understanding of the health risks associated with mixed-agent exposures. From this the discussion moves to the research needs for assessing the cumulative health risks from aggregate exposures to ionizing radiation and chemicals. The evaluation indicates that essentially no guidance has been provided for conducting risk assessm...Continue Reading

Citations

Jul 22, 2011·International Journal of Environmental Research and Public Health·Ari S LewisSharan L Campleman
Oct 19, 2010·Journal of Environmental Radioactivity·M García-TalaveraL Ramos
Jun 12, 2012·International Journal of Cancer. Journal International Du Cancer·Shinobu HiranoYoshiya Shimada
Oct 10, 2013·International Journal of Cancer. Journal International Du Cancer·Tatsuhiko ImaokaYoshiya Shimada
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Tatsuhiko ImaokaYoshiya Shimada
Dec 23, 2016·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Emily JoachimSana Waheed
Nov 6, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Konstadina GrivaMarjorie Wai Yin Foo

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