Chronic heart failure: Ca(2+), catabolism, and catastrophic cell death

Biochimica Et Biophysica Acta
Geoffrey W ChoJ A Hill

Abstract

Robust successes have been achieved in recent years in conquering the acutely lethal manifestations of heart disease. Many patients who previously would have died now survive to enjoy happy and productive lives. Nevertheless, the devastating impact of heart disease continues unabated, as the spectrum of disease has evolved with new manifestations. In light of this ever-evolving challenge, insights that culminate in novel therapeutic targets are urgently needed. Here, we review fundamental mechanisms of heart failure, both with reduced (HFrEF) and preserved (HFpEF) ejection fraction. We discuss pathways that regulate cardiomyocyte remodeling and turnover, focusing on Ca(2+) signaling, autophagy, and apoptosis. In particular, we highlight recent insights pointing to novel connections among these events. We also explore mechanisms whereby potential therapeutic approaches targeting these processes may improve morbidity and mortality in the devastating syndrome of heart failure.

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Citations

Apr 27, 2017·The Journal of Physiology·Kristina LorenzJoachim P Schmitt
Mar 20, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tian LiShi Hu
Feb 23, 2017·Journal of Muscle Research and Cell Motility·Mélanie GueffierMarie Demion
Apr 30, 2017·Experimental and Therapeutic Medicine·Peiying Zhang
Dec 25, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Qianqian GuoFan Jiang
Mar 30, 2021·Therapeutic Advances in Cardiovascular Disease·Michael V Genuardi, Paul J Mather
Jun 12, 2021·Circulation Research·Min XieJoseph A Hill

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