Chronic heat improves mechanical and metabolic response of trained rat heart on ischemia and reperfusion

The American Journal of Physiology
E LevyM Horowitz

Abstract

Cardiac mechanics and metabolic performance were studied in isolated perfused hearts of rats subjected to a combined chronic stress of heat acclimation and swimming training (EXAC) or swimming training alone (EX). Diastolic (DP) and systolic pressures (SP), coronary flow (CF), and oxygen consumption were measured during normoperfusion (80 mmHg), and the appearance of ischemic contracture (IC), DP, and SP were measured during progressive graded ischemia, total ischemia (TI), and reperfusion insults. ATP, phosphocreatine, and intracellular pH were measured during TI and reperfusion with 31P nuclear magnetic resonance spectroscopy. During normoperfusion, SP and cardiac efficiency (derived from rate-pressure product-oxygen consumption relationships) were the highest in the 2-mo EXAC hearts (P < 0.0001). During progressive graded ischemia, the development of IC (percentage of total hearts) was similar in both EXAC and EX hearts; the only significant difference was confined to the 1- vs. 2-mo groups. The onset of IC was delayed in the EXAC hearts and, on reperfusion, recovery, particularly of DP, was significantly improved in the latter. After TI, EXAC hearts retained 30% of the ATP pool and there was a delayed decline in intracellul...Continue Reading

Citations

Nov 14, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Michal Horowitz
Sep 4, 2009·European Journal of Applied Physiology·Andrew T GarrettJames D Cotter
Oct 23, 2002·Journal of Applied Physiology·Mirit EynanMichal Horowitz
Aug 21, 2010·Journal of Applied Physiology·Santiago LorenzoChristopher T Minson
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·E MiritM Horowitz
Oct 1, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Einat KodeshMichal Horowitz
Aug 15, 2017·Frontiers in Physiology·Michal Horowitz
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Michal Horowitz

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