Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection

Scientific Reports
Simon A BabayanColin Selman

Abstract

Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic infections by avoiding and suppressing host immunity. Yet, how age affects immune responses to lifelong parasitic infection is poorly understood. To disentangle the processes involved, we employed supervised statistical learning techniques to identify which factors among haematopoietic stem and progenitor cells (HSPC), and both innate and adaptive responses regulate parasite burdens and how they are affected by host age. Older mice harboured greater numbers of the parasites' offspring than younger mice. Protective immune responses that did not vary with age were dominated by HSPC, while ageing specifically eroded adaptive immunity, with reduced numbers of naïve T cells, poor T cell responsiveness to parasites, and impaired antibody production. We identified immune factors consistent with previously-reported immune responses to helminths, and also revealed novel interactions between helminths and HSPC maturation. Our approach thus allowed disentangling the concurrent effects of ageing...Continue Reading

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Citations

Aug 2, 2019·Integrative and Comparative Biology·Evelyn C RynkiewiczAmy B Pedersen
Mar 30, 2019·International Journal for Parasitology. Parasites and Wildlife·Melanie ClercAmy B Pedersen

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Methods Mentioned

BETA
dissection
lavage
flow cytometry
ELISA
FACS

Software Mentioned

XGB
Elastic
matplotlib
learn
statsmodels
FlowJo
xgboost
pandas
scikit
XGB )

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