PMID: 36486Jul 27, 1979

Chronic hepatic encephalopathy. Long-term therapy with a branched-chain amino-acid-enriched elemental diet

JAMA : the Journal of the American Medical Association
H FreundJ E Fischer


Therapy of chronic hepatic encephalopathy is often frustrating, limited as it is by the ability to adequately nourish such patients. Protein is needed for repair, but such patients are intolerant of protein. Previous work from this and other laboratories has suggested that the distorted plasma amino acid pattern may be causally related to hepatic encephalopathy. A single, well-studied, long-term patient received therapy with a branched-chain amino-acid-enriched elemental diet that not only enabled adequate nutrition with protein but resulted in improvement in hepatic function as well as reversal of some aspects of hepatic encephalopathy that heretofore have been deemed irreversible. The results confirm that branched-chain-enriched amino acid diets previously successful in the intravenous mode may be successfully used in chronic long-term support of patients with protein intolerance, with improvement in hepatic function secondary to improvement in nutrition.


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Apr 1, 1981·Digestive Diseases and Sciences·C J McClainD H Van Thiel
Apr 1, 1994·The Veterinary Quarterly·D P LaflammeT L Huber
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BeaubernardD Franco
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D HorstC E Atterbury
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·M Muggia-SullamJ E Fischer
May 1, 1982·JPEN. Journal of Parenteral and Enteral Nutrition·M H Seltzer
Jan 1, 1981·Gastroenterologia Japonica·M OkitaH Nagashima

Related Concepts

Hepatic Encephalopathy
Dysarthria, Guttural
Brain Chemistry
Fulminant Hepatic Failure With Cerebral Edema
Dietary Proteins
Amino Acids, Branched-Chain

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