Chronic hepatitis C associated with anti-liver/kidney microsome-1 antibody is not a subgroup of autoimmune hepatitis

Journal of Gastroenterology
H MiyakawaK Kiyosawa

Abstract

To determine whether "autoimmune hepatitis type IIb" should be categorized as a subgroup of autoimmune hepatitis, we conducted a clinicopathological study of 25 adult Japanese patients who were positive for anti-liver/kidney microsome-1 (anti-LKM-1) anti-body and infected with the hepatitis C virus (HCV). Anti-LKM-1 was determined by indirect immunofluorescence and by the double immunodiffusion assays we have developed. Twenty-two patients did not present any unusual symptoms or any associated diseases during the course of their chronic HCV infection. The spectrum of HCV genotypes of these patients did not significantly differ from that of anti-LKM-1-negative Japanese patients with chronic hepatitis C. Histological examination of liver biopsy specimens showed the usual characteristics of chronic hepatitis C and lack of characteristics of autoimmune hepatitis type I. No disease-specific HLA haplotypes were noted, and HLA-DR4, which is detectable in 88.7% of Japanese patients with autoimmune hepatitis type I, was detected in only 50.0% of our group, the same rate as the background frequency. Prednisolone was effective in none of the six patients treated, but interferon was effective in six of ten treated patients (60%). From thes...Continue Reading

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Citations

Jul 30, 2002·European Journal of Internal Medicine·G N. DalekosN Gatselis
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke M HennesUNKNOWN International Autoimmune Hepatitis Group
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Albert J CzajaUNKNOWN American Association for the Study of Liver Disease

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