PMID: 8583136Nov 1, 1995Paper

Chronic hepatitis C in patients with normal or near normal alanine aminotransferase levels: the role of interferon alpha 2b therapy

Journal of Hepatology
D H Van ThielL Friedlander

Abstract

Interferon is the only approved therapy for chronic hepatitis occurring as a consequence of an infection with the hepatitis C virus. Because interferon is expensive, has a large number of untoward effects and its efficacy is not guaranteed, many physicians limit their use of this therapy to those with histologically advanced but not end-stage cirrhotic disease. Moreover, most cases are biopsied only after 6 months or more of abnormal alanine aminotransferase levels have been documented. The rationale for this approach to patients with hepatitis C virus infection has not been demonstrated. In the present study, a total of 37 patients with alanine aminotransferase levels < 1.5 upper limits of normal (59 IU/l or less) who were HCV-RNA positive by reverse transcriptase polymerase chain reaction, were selected for interferon treatment, having been identified as having hepatitis C virus disease as the result of a screening Ab-HCV test confirmed with a positive radio immune blotting assay. Once identified, each subject underwent a percutaneous liver biopsy and was tested for the presence of HBsAg, Ab-HBs and HBV-DNA. All liver biopsies were read and graded according to the criteria of Knodell et al. Each subject was treated with inter...Continue Reading

References

Jul 11, 1991·The New England Journal of Medicine·P FarciR H Purcell
Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di Bisceglie, J H Hoofnagle
Nov 30, 1989·The New England Journal of Medicine·G L DavisUNKNOWN Hepatitis Interventional Therapy Group
Nov 30, 1989·The New England Journal of Medicine·A M Di BisceglieJ H Hoofnagle
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Apr 1, 1993·Digestive Diseases and Sciences·S IinoS Yamamoto

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Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SangiovanniG Minoli
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T V InglesbyD L Thomas
Feb 15, 2001·Current Gastroenterology Reports·M W Russo, R S Brown
Jan 6, 2000·Journal of Hepatology·N C Tassopoulos
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiF Montagnese
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiUNKNOWN Committee on HCV carriers with normal alanine aminotransferase levels of the Italian Association for the Study of the Liver
Jun 10, 2000·British Journal of Haematology·C McMahonO P Smith
Jun 10, 2000·Journal of Viral Hepatitis·L A KondiliA Mele
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S C GordonJ K Albrecht
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre PradatChristian Trépo
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nicholas C TassopoulosAngelos E Hatzakis
Jul 2, 1998·Journal of Clinical Gastroenterology·M A SerraJ M Rodrigo
Jul 15, 1999·Journal of Clinical Gastroenterology·H ZylberbergP Berthelot
Feb 8, 1997·Lancet·C PuotiS Resta
Mar 15, 1997·Medizinische Klinik·D M Alscher, J C Bode
May 9, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Claudio PuotiUNKNOWN Club Epatologico Ospedaliero (Hospital Liver Club - CLEO)
Apr 9, 2001·Clinics in Liver Disease·P MarcellinS Lévy
Oct 24, 2003·The American Journal of Gastroenterology·David H Van ThielSteven Creech
May 26, 1998·Multiple Sclerosis : Clinical and Laboratory Research·O A KhanS S Dhib-Jalbut
Oct 9, 2001·International Journal of STD & AIDS·M G Brook, UNKNOWN European Branch of the Internatioanl Union against Sexually Transmitted Infection and the European Office of the World Healt
Aug 28, 2004·The American Journal of Gastroenterology·Ira M JacobsonHulya Levendoglu
Jan 23, 1998·Scandinavian Journal of Gastroenterology·I NordøyE Schrumpf
Mar 13, 2012·Journal of Viral Hepatitis·C PuotiM G Elmo

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