PMID: 11920814Mar 29, 2002Paper

Chronic hepatitis C infection: influence of the viral load, genotypes, and GBV-C/HGV coinfection on the severity of the disease in a Brazilian population

Journal of Medical Virology
Leila M M B PereiraIan G McFarlane

Abstract

The distributions of the different genotypes of the hepatitis C virus (HCV) and GBV-C virus (GBV-C/HGV) vary geographically and information worldwide is still incomplete. In particular, there are few data on the distribution of genotypes (and their relationship to the severity of liver disease) in South America. Findings are described in 114 consecutive patients from Northeast Brazil (median age 52 years, range 18-72 years) who had abnormal levels of serum aminotransferases and seropositivity for HCV RNA. The patients were recruited from an outpatient clinic between November 1997 and April 1998. Quantitative HCV RNA and GBV-C/HGV RNA estimations were carried out by double-nested polymerase chain reaction (PCR) using primers from the 5'-untranslated regions (UTRs) of the genomes. HCV genotypes were determined by restriction fragment length polymorphism (RFLP) analysis with 5'-UTR primers and by PCR with type-specific 5'-UTR primers. GBV-C/HGV-RNA genotypes were determined by RFLP with specific 5'-UTR primers and phylogenetic trees were constructed using the Neighbour-Joining and Drawtree programs. Histological features were graded and staged according to international criteria. Of the 114 patients, 35 (30.7%) patients had cirrho...Continue Reading

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Citations

Jun 1, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mark D BerzsenyiStuart K Roberts
Aug 12, 2004·Journal of Gastroenterology and Hepatology·Sidhartha HazariSubrat Kumar Acharya
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Jul 3, 2021·Viruses·Keyla Santos Guedes de SáAntonio Carlos Rosário Vallinoto

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