Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage

World Journal of Gastroenterology : WJG
Pamela ValvaMaría Victoria Preciado

Abstract

Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus (HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C (CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are (1) the physical ones based on imaging techniques; and (2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss: (1) class I serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes; (2) class II biomarkers that are indire...Continue Reading

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Citations

Jul 19, 2018·Expert Review of Molecular Diagnostics·Sreelakshmi KothaKeyur Patel
Aug 14, 2019·Healthcare Informatics Research·Nahla H BarakatNadia Ahmed
Oct 19, 2017·Scientific Reports·Daniela Alejandra RiosMaría Victoria Preciado
Jul 3, 2018·World Journal of Gastroenterology : WJG·Malgorzata PawlowskaKrzysztof Domagalski

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