Chronic high dose captopril decreases total heart rate variability and increases heart rate in C57BL/6J mice

International Journal of Cardiology
F ToumaC S McLachlan

Abstract

The effects of high dose captopril, within the therapeutic range, on autonomic activity are unknown in those with normal cardiovascular function. Thus the study aims were to assess the effects of high dose captopril on autonomic function in mice. Autonomic activity was measured using heart rate variability (HRV). ECG recordings were obtained from 18 Male C57BL/6J mice (20-25 g) subdivided into control (N=8) or mice receiving oral captopril (0.688 mg/ml captopril in the drinking water for 6 weeks, N=10). HRV results for linear and non-linear parameters were attenuated following chronic captopril for 6 weeks compared to control. Captopril was associated with a trend for an increase in average heart rate and approximate entropy (ApEn), a non-linear measure of HRV decreased significantly compared to control (p<0.05). In conclusion high dose captopril reduces total HRV and increases heart rate in normotensive mice with normal cardiac function.

References

Jul 1, 1997·Journal of Cardiovascular Pharmacology·P W KamenA M Tonkin
May 23, 2002·Journal of Hypertension·Robert Wolk, Virend K Somers
Dec 9, 2004·Progress in Cardiovascular Diseases·Joseph WongPeter R Kowey
Mar 14, 2007·International Journal of Cardiology·Nipon ChattipakornSiriporn Chattipakorn

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