Chronic high-dose glycine nutrition: effects on rat brain cell morphology

Biological Psychiatry
S. ShohamU. Heresco-Levy

Abstract

Facilitation of N-methyl-D-aspartate (NMDA) receptor-mediated neurotransmission via administration of glycine site agonists of the NMDA receptor (e.g., glycine, D-serine), and glycine transport inhibitors may represent an innovative pharmacologic strategy in schizophrenia; however, given the potential involvement of NMDA receptors in the neurotoxicity of excitatory amino acids, possible neurotoxic effects of glycinergic compounds need to be explored. Furthermore, studying brain adaptations to chronic administration of glycine site agonists may provide insights into the therapeutic mechanisms of these drugs. Adult rats were randomized to one of three nutritional regimens (no glycine supplementation, 1 g/kg/day, or 5 g/kg/day glycine supplementation) and to one of three treatment durations (1, 3, or 5 months). Serum glycine and serine levels at sacrifice and brain sections were examined using histologic markers of neurodegeneration (cresyl violet and silver impregnation staining) and immunohistochemical staining of glial fibrillary acidic protein, microtubule-associated protein, and neurofilament 200. To explore additional neural adaptations to high-dose glycine treatment, immunostaining was also performed for class B, N-type Ca(...Continue Reading

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Citations

Oct 24, 2007·Psychopharmacology·Sumie LeungPradeep J Nathan
Oct 19, 2004·Experimental Brain Research·A BarthD W Newell
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Uriel Heresco-Levy
Jul 10, 2007·Schizophrenia Bulletin·John A Gray, Bryan L Roth
Feb 22, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Uriel Heresco-LevyDaniel C Javitt
Nov 3, 2005·Expert Opinion on Emerging Drugs·Uriel Heresco-Levy
Jul 12, 2016·International Journal of Molecular Sciences·Tsutomu SasakiTadahiro Kitamura
Oct 13, 2016·The Journal of Physiological Sciences : JPS·Yoshiro IshimaruTsutomu Sasaki
Sep 10, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Charles R Yang, Long Chen
Oct 16, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel C JavittHenry Sershen
Jul 28, 2004·Molecular Psychiatry·D C Javitt
Jul 15, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tsutomu SasakiTadahiro Kitamura
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson
Feb 25, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Eduarda CerónNoé Alvarado-Vásquez
Mar 25, 2017·Oxidative Medicine and Cellular Longevity·Meerza Abdul RazakSenthilkumar Rajagopal
Feb 26, 2019·Frontiers in Psychiatry·Shi-Ning DengFei Li

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