Chronic high Epstein-Barr viral load carriage in pediatric small bowel transplant recipients.

Pediatric Transplantation
Audrey H LauMichael Green

Abstract

The development of EBV infection and PTLD is normally associated with a high EBV load in peripheral blood. Often, children undergoing primary or reactivation of EBV infection subsequent to ITx will have chronically elevated EBV loads. To better understand this phenomenon and its consequences, we retrospectively reviewed the records of children who underwent ITx (either isolated or part of multivisceral transplantation) at our center from 1992 to 2007, to identify chronic high EBV load carriers in this population. CHL state was defined as the presence of high load for >50% of samples for greater than or equal to six months following either asymptomatic infection or complete clinical resolution of EBV disease/PTLD. Thirty-five CHL carriers were identified from our patient population. Pretransplant serologies were available on 34 of these patients: 17 were EBV negative and 17 seropositive; one had unknown EBV serostatus prior to transplant. Seven of the 17 seronegative patients developed their CHL carrier state at the time of their primary EBV infection. Thirteen of the 35 (37%) HLC patients developed EBV disease after meeting the definition of high-load carrier states. EBV-related diseases developing in CHL carriers included EBV ...Continue Reading

References

Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D T RoweM Green
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael Green, Steven A Webber
Jan 24, 2006·Lancet·Steven A WebberUNKNOWN Pediatric Heart Transplant Study
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GreenJ Reyes
Feb 24, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael Green, Steven A Webber
Jan 24, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A BinglerS A Webber
Apr 10, 2008·Pediatric Transplantation·Michael GreenGeorge Mazareigos

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Citations

Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Luciana Cristina Fagundes GequelinCarmem M Bonfim
Mar 2, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Patrizia Comoli, Fabrizio Ginevri
Apr 19, 2016·Best Practice & Research. Clinical Gastroenterology·Aparna Rege, Debra Sudan
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·U D AllenUNKNOWN AST Infectious Diseases Community of Practice
Nov 8, 2014·British Journal of Haematology·Augusto LauroAntonio D Pinna
Nov 1, 2013·Clinical & Developmental Immunology·Martin MynarekBritta Maecker-Kolhoff
Jul 28, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V R Dharnidharka
Oct 10, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ryan J StubbinsJutta K Preiksaitis
Feb 9, 2013·Expert Review of Clinical Immunology·Stephanie Ruf, Hans-Joachim Wagner
May 26, 2017·Pediatric Transplantation·Masaki Yamada, Andrew J Nowalk
Jun 24, 2016·Microbiology Spectrum·Andrew Nowalk, Michael Green

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