Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight

American Journal of Physiology. Gastrointestinal and Liver Physiology
Fei WangPatrick Tso

Abstract

The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), enhance postprandial insulin secretion, promote adipogenesis, and regulate gastrointestinal motility and food intake. To date, a consensus on how the incretin response is altered in obesity is lacking. We investigated the effects of chronic high-fat (HF) feeding on incretin secretion in the lymph fistula rat model. Male Sprague-Dawley rats (8 wk) were provided a semipurified AIN93M HF or low-fat (LF) diet ad libitum for 3 or 13 wk; a HF pair-fed (HF-PF) group was included as a control during the 3-wk feeding trial. Energy intake, body weight, and body composition were regularly monitored. At the culmination of the feeding period, an intestinal lymphatic duct cannula and duodenal infusion tube were installed. All animals were challenged with a 3-ml Ensure bolus (3.125 kcal/animal) to measure lymphatic incretin secretion. Despite a significantly higher energy intake, both the 3-wk and 13-wk HF-fed animals did not have an increase in body weight and only a slight increase in body fat compared with LF-fed rats. Following the duodenal Ensure challenge, the 3-wk and 13-wk HF-fed rats had significantly greater lymphatic GIP a...Continue Reading

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Citations

May 31, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean-Philippe KriegerShin J Lee
Jan 18, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nino JejelavaMyrtha Arnold
Mar 16, 2017·American Journal of Physiology. Endocrinology and Metabolism·Judith N GorskiMaria E Trujillo
Oct 18, 2019·JCI Insight·Ki-Suk KimDarleen A Sandoval

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