Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats

Biochemical Pharmacology
Hao Zheng, Yong-Sheng Yu

Abstract

In hypertensive patients, increased oxidative stress is thought to be one important cause of vascular dysfunction. Recently, it has been suggested that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical and peroxynitrite, the most cytotoxic chemicals of reactive oxygen species (ROS). Herein, we investigated the protective effect of chronic treatment with hydrogen-rich saline (HRS) against vascular dysfunction in SHR and the underlying mechanism. The 8-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats (WKY) were randomized into HRS-treated (6ml/kg/day for 3 months, i.p.) and vehicle treated group. Treatment with HRS ameliorated vascular dysfunction including aortic hypertrophy and endothelial function in SHR. Treatment with HRS had no significant effect on blood pressure, but it significantly improved baroreflex function in SHR. Treatment with HRS abated oxidative stress, restored antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and catalase, and suppressed NADPH oxidase. Furthermore, treatment with HRS depressed pro-inflammatory cytokines expression including IL-6 and IL-1β and suppressed NF-κB activation, restored mitochondrial f...Continue Reading

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Citations

Aug 5, 2014·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Qi GuXiao-Ze Wang
May 17, 2015·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Feng WuJinzhong Feng
Dec 6, 2012·Molecular and Cellular Biochemistry·Wen-Wen CaiJin-Hua Cai
Nov 19, 2019·Acta Biochimica Et Biophysica Sinica·Geru TaoShucun Qin
Mar 22, 2014·Molecular and Cellular Biochemistry·Hai-Guang XinXiao-Hui Miao
Sep 24, 2020·Oxidative Medicine and Cellular Longevity·Mengling YangMingyi Zhao
Sep 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Berk
Jan 30, 2021·Oxidative Medicine and Cellular Longevity·Yaxing ZhangLequan Zhou
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiongge HuAnwen Shao
Sep 22, 2020·Current Pharmaceutical Design·Jan SlezakMiroslav Barancik
Sep 24, 2020·Current Pharmaceutical Design·Sergej M Ostojic
Nov 14, 2020·Current Pharmaceutical Design·Jonatas E Nogueira, Luiz G S Branco

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