Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats.

Molecular and Cellular Biochemistry
Yong-Sheng Yu, Hao Zheng

Abstract

In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. In the current study, we explored the effect of chronic treatment with hydrogen-rich saline (HRS) on left ventricular hypertrophy in spontaneously hypertensive rats (SHR). The 8-week-old male SHR and age-matched Wistar-Kyoto rats (WKY) were randomized into HRS-treated (6 ml/kg/day for 3 months, i.p.) and vehicle-treated groups. HRS treatment had no significant effect on blood pressure, but it effectively attenuated left ventricular hypertrophy in SHR. HRS treatment abated oxidative stress, restored the activity of antioxidant enzymes including GPx, GST, catalase, and SOD, suppressed NADPH oxidase activity and downregulated Nox2 and Nox4 expression in left ventricles of SHR. HRS treatment suppressed pro-inflammatory cytokines including IL-1β, IL-6, TNF-α, and MCP-1, and inhibited NF-κB activation through preventing IκBα degradation in left ventricles of SHR. HRS treatment preserved mitochondrial function through r...Continue Reading

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Citations

Jun 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tyler W LeBaronJan Slezak
Dec 6, 2012·Molecular and Cellular Biochemistry·Wen-Wen CaiJin-Hua Cai
Jan 21, 2016·Oxidative Medicine and Cellular Longevity·Csaba CsonkaTamás Csont
May 15, 2015·Journal of Diabetes Investigation·Ying TangJiangang Long
Nov 12, 2016·Frontiers in Pharmacology·Yaxing ZhangTinghuai Wang
Sep 26, 2017·Molecular Medicine Reports·Yaxing ZhangTinghuai Wang
Jun 15, 2018·Clinical and Experimental Hypertension : CHE·Hiroki MatsuokaAkiko Noda
Mar 22, 2014·Molecular and Cellular Biochemistry·Hai-Guang XinXiao-Hui Miao
Nov 14, 2020·Current Pharmaceutical Design·Jonatas E Nogueira, Luiz G S Branco

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