Chronic hyperleptinemia results in the development of hypertension in pregnant rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Ana C PaleiJoey P Granger

Abstract

Despite the fact that obesity is a major risk factor for preeclampsia (PE), the pathophysiological mechanisms whereby obesity and metabolic factors such as leptin increase this risk are unclear. While human data have shown that hyperleptinemia is associated with PE, the long-term effect of hyperleptinemia on blood pressure during pregnancy is unknown. Thus we tested the hypothesis whether chronic circulating leptin elevations in pregnant rats increase blood pressure and placental factors known to play a role in PE. On gestational day (GD)14, rats were assigned to the normal pregnant group with food intake ad libitum (control), leptin-treated (0.5 μg·kg(-1)·min(-1) ip) pregnant group with food intake ad libitum (pregnant+LEP), and normal pregnant group with food intake adjusted to the food intake of pregnant+LEP rats (pregnant-FR). On GD19, mean arterial pressure (MAP) was assessed and tissues were collected. Serum leptin concentration was elevated in pregnant+LEP compared with control and pregnant-FR (18.0 ± 2.8 vs. 0.8 ± 0.1 vs. 0.3 ± 0.1 ng/ml; P < 0.05), which was associated with increased MAP (121.3 ± 8.1 vs. 102.4 ± 2.4 vs. 101.3 ± 1.8 mmHg; P < 0.05). Food intake and body weight were reduced in pregnant+LEP and pregnant-F...Continue Reading

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Citations

Nov 17, 2015·Biomolecules·Frank T SpradleyJoey P Granger
Nov 5, 2016·Diabetes/metabolism Research and Reviews·Stacey HokkeLuise A Cullen-McEwen
Mar 23, 2017·Endocrine Reviews·Nadia BerkaneNathalie Chabbert-Buffet
Dec 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T Spradley
Feb 14, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Hijab AhmedStyliani Goulopoulou
May 31, 2020·International Journal of Molecular Sciences·Lauren E St-GermainAlexander G Beristain
Oct 9, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Frank T SpradleyJoey P Granger
Nov 19, 2019·International Journal of Hypertension·Elżbieta Poniedziałek-CzajkowskaBożena Leszczyńska-Gorzelak
Jan 9, 2019·Frontiers in Physiology·Patricio Lopez-JaramilloCamilo Felix
Mar 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Ana C PaleiFrank T Spradley

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