Abstract
Abnormal levels of plasma high-density lipoproteins (HDL) commonly reflect altered metabolism of the major HDL-apolipoprotein A-I (apo A-I). It is well known that thyroid hormones are involved in the regulation of lipoprotein metabolism, inducing significant changes in the concentration, size, and composition of plasma HDL. The purpose of this study was to evaluate the mechanisms responsible of the decreased HDL-apo A-I in chronic thyroidectomized rats (Htx) and to assess the role of HDL structure in apo A-I turnover. Htx rats were found to have a 3-fold increase in low-density lipoprotein-cholesterol (LDL-C), whereas HDL-C and apo A-I showed a 25.9% and 22.6% decrease compared to controls (P <.05), thus suggesting a defect in HDL metabolism. Turnover studies of apo A-I incorporated into normal HDL, using exogenous (125)I-radiolabeling, confirmed an altered fractional catabolic rate (FCR) in Htx rats (0.097 +/- 0.009 d(-1) v 0.154 +/- 0.026 d(-1) for Htx and control rats, respectively, P <.005). Apo A-I production rates calculated with autologous HDL data showed that apo A-I synthesis was decreased to a higher extent than the already reduced apo A-I catabolism, thus explaining the low apo A-I plasma levels in Htx rats. Composit...Continue Reading
Citations
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