Chronic hypothyroidism induces abnormal structure of high-density lipoproteins and impaired kinetics of apolipoprotein A-I in the rat

Metabolism: Clinical and Experimental
Claudia Huesca-GómezO Perez-Mendez

Abstract

Abnormal levels of plasma high-density lipoproteins (HDL) commonly reflect altered metabolism of the major HDL-apolipoprotein A-I (apo A-I). It is well known that thyroid hormones are involved in the regulation of lipoprotein metabolism, inducing significant changes in the concentration, size, and composition of plasma HDL. The purpose of this study was to evaluate the mechanisms responsible of the decreased HDL-apo A-I in chronic thyroidectomized rats (Htx) and to assess the role of HDL structure in apo A-I turnover. Htx rats were found to have a 3-fold increase in low-density lipoprotein-cholesterol (LDL-C), whereas HDL-C and apo A-I showed a 25.9% and 22.6% decrease compared to controls (P <.05), thus suggesting a defect in HDL metabolism. Turnover studies of apo A-I incorporated into normal HDL, using exogenous (125)I-radiolabeling, confirmed an altered fractional catabolic rate (FCR) in Htx rats (0.097 +/- 0.009 d(-1) v 0.154 +/- 0.026 d(-1) for Htx and control rats, respectively, P <.005). Apo A-I production rates calculated with autologous HDL data showed that apo A-I synthesis was decreased to a higher extent than the already reduced apo A-I catabolism, thus explaining the low apo A-I plasma levels in Htx rats. Composit...Continue Reading

Citations

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Jul 16, 2011·Journal of Thyroid Research·Martha FrancoOscar Pérez-Méndez
Mar 6, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Nilda Espinola-ZavaletaOscar Pérez-Méndez
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Dec 20, 2012·International Journal of Endocrinology·Adriana SantiVania Lucia Loro
Feb 21, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Oscar Pérez-MéndezGérald Luc
Aug 29, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Oscar Pérez-MéndezBlanca Aguilar-Herrera
Dec 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Oscar Pérez-MéndezGilberto Vargas-Alarcón
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