PMID: 8941532Nov 1, 1996Paper

Chronic hypoxia alters nitric oxide-dependent pulmonary vascular responses in lungs of newborn pigs

Journal of Applied Physiology
C D Fike, M R Kaplowitz

Abstract

Almost all of the studies evaluating the effect of chronic hypoxia on lung nitric oxide production have been performed in adult animals. Because results of studies in adult lungs should not be extrapolated to represent the newborn lung, we performed studies to determine whether decreased nitric oxide production might be involved in the pathogenesis of chronic hypoxia-induced pulmonary hypertension in newborns. We kept newborn pigs in chambers filled with room air (control) or 11-12% O2 for either 3-5 (short) or 10-12 (long) days. Using isolated lungs, we measured pulmonary vascular responses to agents that either stimulate or inhibit the synthesis of nitric oxide. To define the vascular sites of altered production of nitric oxide, we applied the micropuncture technique and measured small venular pressures before and after treatment with a nitric oxide synthesis inhibitor. Pulmonary vascular responses to acetylcholine were blunted in chronically hypoxic piglets of both the short and long groups. The nitric oxide synthesis inhibitor had a different effect in the lungs of control piglets than in those of chronically hypoxic piglets of the long but not of the short group. For the long group, the nitric oxide synthesis inhibitors ca...Continue Reading

References

Jun 1, 1992·British Journal of Pharmacology·S F LiuP J Barnes
Aug 1, 1991·Pediatric Research·T M Zellers, P M Vanhoutte
Oct 1, 1989·Journal of Applied Physiology·A L Hyman, P J Kadowitz
Dec 1, 1988·Journal of Applied Physiology·E C OrtonK R Stenmark
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Feb 1, 1994·Journal of Applied Physiology·T C IsaacsonS L Archer
Aug 1, 1995·American Journal of Respiratory Cell and Molecular Biology·P W ShaulR A Star
Dec 1, 1994·Journal of Applied Physiology·C D Fike, M R Kaplowitz
Jan 1, 1993·Journal of Applied Physiology·R D Russ, B R Walker

❮ Previous
Next ❯

Citations

Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Usha Raj, Larissa Shimoda
Nov 2, 2004·Journal of Applied Physiology·Candice D FikeSandra L Pfister
Apr 2, 2005·Journal of Applied Physiology·Candice D FikeMark R Kaplowitz
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Shuhei TanakaHiroaki Shimokawa
Feb 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeMark R Kaplowitz
May 10, 2005·Pediatric Pulmonology·Karen M Binns-LovemanCandice D Fike
Aug 10, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Candice D FikeJudy L Aschner
Dec 24, 2014·American Journal of Respiratory Cell and Molecular Biology·Candice D FikeJudy L Aschner
Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J W BerkenboschT Perreault
Jul 4, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·C D FikeM Bousamra
Sep 2, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeJudy L Aschner
Feb 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna DikalovaCandice D Fike
Sep 14, 1999·The American Journal of Physiology·C D Fike, M R Kaplowitz
Nov 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joyce E TurleyCandice D Fike
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeSandra L Pfister
Jul 14, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen E DennisCandice D Fike
Aug 21, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anna DikalovaCandice D Fike
Jul 25, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeJane A Madden
Mar 6, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Judy L AschnerCandice D Fike
May 13, 1999·Early Human Development·P W Shaul
Nov 14, 1997·Seminars in Perinatology·P W Shaul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.