PMID: 8945733Nov 1, 1996Paper

Chronic hypoxia induces modification of the N-methyl-D-aspartate receptor in rat brain

Neuroscience Letters
P PichiuleA Arregui

Abstract

This study examined [3H]MK-801 binding to the N-methyl-D-aspartate (NMDA) receptor in membranes prepared from cerebral cortex, hippocampus and corpus striatum of 3 week old rats exposed to 10 weeks of intermittent hypobaric hypoxia (4300 m; 450 Torr) and compared results with those of normoxic controls. The cortex, hippocampus and striatum of hypoxic animals had a 36, 35 and 31% reduction in binding sites (Bmax) and a 29, 32 and 17% decrease (reflecting increased affinity) in the dissociation constant (Kd) when compared to controls. In the cerebral cortex, both glutamate (100 microM) and glycine (10 microM) enhanced 3[H]MK-801 binding by two to 3-fold. Coagonist glutamate, however, had a higher EC50 (0.44 microM) in the hypoxic cortical membranes when compared to controls (0.28 microM). No significant differences were found in the EC50 of glycine. The results show that the NMDA receptor is altered in several brain regions of rats developing in a hypoxic environment.

References

Jun 1, 1977·International Journal of Biometeorology·P S Timiras
Apr 1, 1992·Neurology·R L Albin, J T Greenamyre
Mar 1, 1992·Journal of Neurochemistry·M A PiggottR H Perry
May 1, 1991·Journal of Neurochemistry·I J Reynolds, A M Palmer
Oct 1, 1991·Neurology·A ArreguiD Arbaiza
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jul 7, 1995·Neuroscience Letters·J C ChávezA Arregui
Oct 1, 1994·Cephalalgia : an International Journal of Headache·A ArreguiH Umeres
Feb 14, 1994·Neuroscience Letters·D J HoffmanM Delivoria-Papadopoulos

❮ Previous
Next ❯

Citations

Mar 31, 2005·Neuropsychology Review·Javier Virués-OrtegaBernardino Alcázar
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Barry W RowDavid Gozal
Nov 17, 2005·Psychosomatics·Jason E SchillerstromDonald R Royall
Aug 16, 2005·Brain Research. Developmental Brain Research·Lakshmi RamanRaghavendra Rao
Sep 19, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angela Navarrete-Opazo, Gordon S Mitchell
Jan 1, 2015·Journal of Applied Physiology·Jason H MateikaBlake Ivers
Jan 1, 2016·Current Behavioral Neuroscience Reports·Joanna L StollingsE Wesley Ely
Sep 25, 2003·Journal of Neuropathology and Experimental Neurology·Juan Manuel EncinasJosé Rodrigo
Apr 8, 1999·Journal of Applied Physiology·J A BoeroT A Woolsey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.