Chronic hypoxia inhibits postnatal maturation of porcine intrapulmonary artery relaxation

The American Journal of Physiology
R M TullohS G Haworth

Abstract

Neonatal pulmonary hypertension is associated with increased pulmonary vascular reactivity. We studied the responses of isolated porcine intrapulmonary arteries after exposure of piglets to chronic hypobaric hypoxia (CHH) from 0 to 2.5, 3 to 6, or 14 to 17 days of age. CHH inhibited the postnatal development of endothelium-dependent vasorelaxation to acetylcholine (ACh) and the calcium ionophore A-23187. Basal accumulation of guanosine 3', 5'-cyclic monophosphate (cGMP) was unaffected, but cGMP response to ACh was inhibited. Endothelium-independent relaxation to nitric oxide (NO) and zaprinast (a phosphodiesterase inhibitor) was also inhibited, but cGMP accumulation in response to these agonists was normal. The ability of sodium nitroprusside (SNP) to cause vasorelaxation and increase cGMP accumulation was unaffected. Contractile responses to potassium chloride and prostaglandin F2 alpha (PGF2 alpha) were similar to normal after exposure from birth and 3 days and were decreased in the older group, but the ability of NG-monomethyl-L-arginine acetate to increase PGF2 alpha-induced contractions decreased. Thus exposure of newborn piglets to CHH causes 1) no increase in contractile responses and 2) impairment of endothelium-depende...Continue Reading

Citations

Feb 9, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·J W BerkenboschT Perreault
Nov 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Joyce E TurleyCandice D Fike
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Margrid B SchindlerSheila G Haworth
Nov 2, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·J BelikA K Tanswell
Dec 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Carla Blum-JohnstonSean M Wilson
Jan 24, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Beata Wojciak-StothardSheila G Haworth
May 13, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anne-Christine PeyterJean-François Tolsa
Nov 7, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yuansheng GaoJ Usha Raj
Mar 8, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carla Blum-JohnstonSean M Wilson
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jean-Marie JouannicA Tuan Dinh-Xuan
Feb 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Candice D FikeMark R Kaplowitz
Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Usha Raj, Larissa Shimoda
Sep 9, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dinesh K Hirenallur-SNancy J Rusch
Sep 28, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laura MorenoFrancisco Perez-Vizcaino

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