PMID: 15373960Sep 18, 2004Paper

Chronic idiopathic intestinal pseudo-obstruction: the need for a multidisciplinary approach to management

The Proceedings of the Nutrition Society
D B Silk

Abstract

At the outset of the research programme into irritable bowel syndrome (IBS) it was perceived that there was a need to develop a symptom-based classification for the patients. Four groups of patients were identified, those with spastic colon syndrome, diarrhoea-predominant spastic colon syndrome, functional diarrhoea and midgut dysmotility. While working with outpatients with IBS it was noted how some of them had suffered symptoms for many years; specifically, a group of patients satisfying the criteria for midgut dysmotility had also suffered from particularly severe and intractable intestinal symptoms. These patients underwent 24 h ambulatory studies of small intestinal motility and the majority were found to have manometric features of chronic idiopathic intestinal pseudo-obstruction (CIIP). To characterise the cause, laparoscopic full-thickness small intestine and colonic biopsies have been obtained in forty-five of the latter group of patients. Of these patients 58% have been found to have complete or partial deficiency of alpha-actin epitope staining in the inner circular layer of small intestinal smooth muscle. This deficiency is believed to represent an important biomarker rather than the cause of CIIP, since alpha-actin...Continue Reading

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Citations

Feb 2, 2008·World Journal of Gastroenterology : WJG·Eugen Florin GeorgescuReanina Ionescu
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Sep 17, 2004·European Journal of Gastroenterology & Hepatology·D B A Silk
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Nov 23, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·David B A Silk, Tim Bowling
Mar 27, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K TwistS Peters

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