Chronic increase of bone turnover markers after biliopancreatic diversion is related to secondary hyperparathyroidism and weight loss. Relation with bone mineral density.

Obesity Surgery
José Antonio BalsaClotilde Vázquez

Abstract

Biliopancreatic diversion (BPD) is the most effective bariatric procedure. Around 70% of these patients have secondary hyperparathyroidism (SH) in the long term as a consequence of calcium and vitamin D malabsorption. This work was aimed to study the influence of SH on bone turnover and its relationship with bone mineral density (BMD). Bone turnover markers were determined in 63 BPD patients and 34 morbidly obese controls. In the BPD group, we also studied the influence of age, loss of weight, common channel length, PTH, vitamin D, and serum calcium on bone turnover as well as its relation with BMD. BPD patients showed significantly higher PTH, osteocalcin, and beta-CTx levels than controls. In the multivariate regression analysis, only PTH (beta=0.42; P=0.0002), menopausal status (beta=0.31; P=0.007) and the percentage of lost BMI (beta=-0.24; P=0.03) significantly predicted the osteocalcin level (R2=0.33; F=9.56; P<0.0001). Similarly, only PTH (beta=0.39; P=0.0005), menopausal status (beta=0.37; P=0.001) and the percentage of lost BMI (beta=-0.23; P=0.04) significantly predicted the beta-CTx level (R2=0.33; F=9.82; P<0.0001). Osteocalcin and beta-CTx levels correlated negatively with BMD at lumbar spine (r=-0.38, P=0.002 and ...Continue Reading

References

Mar 1, 1982·Calcified Tissue International·L J DeftosP A Price
Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A KanisN Khaltaev
Aug 1, 1993·Annals of Medicine·L Risteli, J Risteli
Nov 1, 1996·Calcified Tissue International·R Dresner-PollakS L Greenspan
Oct 1, 1996·Archives of Surgery·B L ChapinP L Carter
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P D Ross, W Knowlton
Aug 26, 1998·World Journal of Surgery·N ScopinaroA Simonelli
Oct 26, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Picard MarceauLorraine A Fitzpatrick
Jan 18, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·N PugnaleP Burckhardt
Jan 30, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Guy H SlaterGeorge A Fielding
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Penelope S CoatesSusan L Greenspan
May 11, 2005·The American Journal of Clinical Nutrition·Jeri W Nieves
Jul 24, 2008·The Journal of Clinical Endocrinology and Metabolism·J FleischerS J Silverberg
Dec 19, 2008·Journal of Endocrinological Investigation·J A BalsaC Vázquez

❮ Previous
Next ❯

Citations

Jan 1, 2013·Gastroenterology Research and Practice·Blaire AndersonMichel Gagner
Aug 27, 2010·Obesity Surgery·Fernando Granado-LorencioBelen Pérez-Sacristán
Jan 15, 2013·Obesity Surgery·Jaime Ruiz-TovarRafael Calpena
Jan 26, 2016·Metabolism: Clinical and Experimental·Marlene Toufic ChakhtouraGhada A El Hajj Fuleihan
Dec 21, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Béatrice BouvardErick Legrand
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W Yu
Jul 19, 2016·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Monica SethiChristine Ren-Fielding
Oct 21, 2016·Obesity Surgery·Jose I Botella-CarreteroHector Escobar-Morreale
Nov 18, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Megan R CrawfordSangeeta R Kashyap
Apr 25, 2012·Nature Reviews. Endocrinology·Bikram S BalTimothy R Koch
Jun 3, 2018·Hormones : International Journal of Endocrinology and Metabolism·Christos SavvidisAnastasia D Dede
Apr 26, 2018·International Journal of Endocrinology·Claudio CasellaNazario Portolani
Mar 17, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·George A FisherUNKNOWN ELECT Study Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.