Chronic indomethacin treatment enhances the portal-systemic collateral vascular response to vasopressin in bile-duct ligated rats

Journal of the Chinese Medical Association : JCMA
Hui-Chun HuangShou-Dong Lee

Abstract

Liver cirrhosis is often accompanied by portal-systemic collateral formation with hemorrhage and encephalopathy. Prostacyclin participates in hyperdynamic circulation and vascular hyporeactiveness to vasoconstrictors in cirrhosis. It has been shown that arginine vasopressin (AVP) induces direct collateral vasoconstriction in portal hypertensive rats, which is potentiated by indomethacin preincubation. However, the influence of chronic indomethacin administration in cirrhosis remains unexplored. This study was performed on male Sprague-Dawley rats with liver cirrhosis induced by common bile duct ligation. They received subcutaneous indomethacin (5 mg/kg/day) or distilled water (control) injection from the 36th to 42nd day after operation. On the 43rd day, systemic and portal hemodynamics were evaluated and the following experiments were performed with an in situ collateral perfusion model: in the first series, concentration-response curves to AVP (10(-10) to 10(-7) M) were obtained; in the second series, flow-pressure curves were plotted (Krebs solution, 6-18 mL/min), where the slope represents an index of collateral vascular resistance (the higher the resistance, the smaller the amount of shunting vessels, that is, the lower th...Continue Reading

References

Mar 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T TsaiK J Lo
May 31, 1988·Biochemical and Biophysical Research Communications·K J SilvermanA C Barger
Sep 1, 1989·The Journal of Surgical Research·J V SitzmannP W Lin
Jan 1, 1985·Journal of Hepatology·S A JenkinsR Shields
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·T TetsukaA R Morrison
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L T SumanovskiC C Sieber
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C C ChanS D Lee
Apr 1, 1958·The Journal of Pathology and Bacteriology·G R CAMERON, S MUZAFFAR HASAN
Apr 22, 2005·Scandinavian Journal of Gastroenterology·Che-Chang ChanShou-Dong Lee
Jun 30, 2005·Journal of the Chinese Medical Association : JCMA·Ching-Chih ChangShou-Dong Lee

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Citations

Jul 28, 2013·Journal of the Chinese Medical Association : JCMA·Ching-Chih ChangShou-Dong Lee
Feb 29, 2020·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Tsung-Hsing HungHsing-Feng Lee

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