Chronic inflammatory changes in the pouch mucosa are associated with cholangitis found on peroperative liver biopsy specimens at restorative proctocolectomy for ulcerative colitis

Scandinavian Journal of Gastroenterology
P AitolaK M Hiltunen

Abstract

The clinical syndrome of primary sclerosing cholangitis (PSC), diagnosed in about 5% of patients with ulcerative colitis (UC), has been shown to be associated with pouchitis after ileal pouch-anal anastomosis. The aim of this study was to ascertain whether UC patients with cholangitis on liver biopsy at proctocolectomy, with or without the clinical syndrome of PSC, have an increased risk of inflammatory changes in the ileal reservoir mucosa and clinical pouchitis. Of the consecutive 81 UC patients treated with restorative proctocolectomy with ileal J reservoir at Tampere University Hospital between 1985 and 1991, 73 with peroperative liver biopsy were included. A peroperative liver biopsy was obtained during proctocolectomy. After a median follow up of 64 months, pouch biopsy specimens were obtained. Periods of clinical pouchitis were diagnosed by means of clinical criteria alone or by clinical criteria combined with the results of previous pouch endoscopies in all patients. Ten patients (14%) showed histologic features consistent with small-duct PSC on liver biopsy. Endoscopic retrograde cholangiography had previously been performed on four of these patients, and all four had large-duct PSC. Patients with cholangitis had signi...Continue Reading

References

Mar 1, 1991·Diseases of the Colon and Rectum·R LöfbergB Tribukait
Feb 1, 1991·Seminars in Liver Disease·J Ludwig
Jan 1, 1990·American Journal of Surgery·S D WexnerS M Goldberg
Jan 1, 1980·Scandinavian Journal of Gastroenterology·E SchrumpfS Ritland
Sep 1, 1981·Digestive Diseases and Sciences·R W ChapmanS Sherlock
Nov 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J LudwigJ T McCall

❮ Previous
Next ❯

Citations

Nov 22, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P DasR J Nicholls
May 19, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hans H WasmuthHelge E Myrvold
Jan 15, 2014·Journal of Crohn's & Colitis·Michael PavlidesRoger Chapman
Jan 1, 2014·Inflammatory Bowel Diseases·Darren N SerilBo Shen
Feb 18, 2020·Frontiers in Medicine·Zaid S Ardalan, Miles P Sparrow
Oct 7, 2006·Current Opinion in Gastroenterology·E B Martins, R W Chapman
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T KuiperE Dekker
Feb 1, 2011·International Journal of Colorectal Disease·Monira RahmanRoger W Chapman
Feb 21, 2018·Inflammatory Bowel Diseases·Caroline NordenvallAnnika Bergquist
Jul 15, 2004·The American Journal of Surgical Pathology·Rhonda K YantissRobert D Odze
Jan 13, 2006·Histopathology·R K Yantiss, R D Odze
Dec 22, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P DasR J Nicholls
Feb 17, 2015·World Journal of Gastroenterology : WJG·A Boudewijn de VriesRinse K Weersma
Jun 20, 2006·Scandinavian Journal of Gastroenterology. Supplement·J S Terhaar Sive DrosteC J J Mulder
Nov 19, 2013·Journal of Crohn's & Colitis·M BlockL Börjesson
Feb 8, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kevin P QuinnLaura E Raffals
Dec 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Katherine FreemanBo Shen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.