Chronic inflammatory demyelinating polyradiculoneuropathy with autonomic involvement

Muscle & Nerve
Kanji YamamotoShu-Ichi Ikeda

Abstract

We report a case of chronic acquired neuropathy predominantly affecting sensory and autonomic nerves. Investigations showed a demyelinating polyradiculoneuropathy with axonal degeneration and depletion of postganglionic noradrenergic fibers in the rectal mucosa. Intravenous immunoglobulin and corticosteroid administration were effective in alleviating symptoms and improving electrophysiological abnormalities. This neuropathy may be a novel variant of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), in which autoimmunoreactivity is directed not only against myelin but also against axon- or ganglion-composing protein. Autonomic nerve involvement does not exclude a diagnosis of CIDP.

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Citations

Aug 28, 2012·Journal of Clinical Neuromuscular Disease·Louis A Tramontozzi, James A Russell
Jul 16, 2013·Autoimmune Diseases·Anna MazzeoGiuseppe Vita
Apr 30, 2013·La Presse médicale·Peter Y K Van den Bergh, Yusuf A Rajabally
Feb 26, 2016·Journal of Clinical Neuromuscular Disease·Ahmet Z Burakgazi, Soufian AlMahameed
Nov 18, 2008·Muscle & Nerve·Véronique BissayGuy Ebinger
Feb 15, 2013·Muscle & Nerve·Kenneth H Fischbeck
May 14, 2005·Current Opinion in Neurology·Hubertus KöllerHans-Peter Hartung
Apr 19, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marcio Luiz Escorcio-BezerraAlex Machado Baeta
Jul 31, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Peter Y K Van den BerghHaluk A Topaloglu

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