Chronic inflammatory demyelinating polyradiculoneuropathy in solid organ transplant recipients: a prospective study

Journal of Neurology, Neurosurgery, and Psychiatry
A Echaniz-LagunaJean-Baptiste Chanson

Abstract

The prevalence and outcome of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) in patients with solid organ transplantation is unknown, and there are no guidelines for the evaluation and treatment of such patients. An 8 year long monocentric prospective study was conducted in which, in a population of 1557 solid organ transplant recipients, the characteristics of 10 consecutive patients (0.6%) who developed a syndrome that fulfilled the clinical, biological and electrophysiological criteria for definite CIDP were investigated. Five patients had liver transplantation, three had kidney transplantation, one had heart transplantation and one had lung transplantation. The mean interval between transplantation and CIDP was 10 months. Six patients developed CIDP after immunosuppressive therapy dosage was decreased and were treated with intravenous immunoglobulin (IVIG) and increased dosage of immunosuppressive therapy. Four patients were treated with IVIG only. Neuropathy improved in all cases, and CIDP had a monophasic course in all patients, with no relapse observed over a mean follow-up of 5 years. CIDP in solid organ transplant recipients is rare, appears in the first year after transplantation, has a monophasic co...Continue Reading

Citations

Dec 24, 2013·Case Reports in Neurological Medicine·D S Younger, Stuart Orsher
Sep 4, 2014·Case Reports in Transplantation·Nirmal S SharmaEnrique Diaz-Guzman
Jan 18, 2018·Journal of the Peripheral Nervous System : JPNS·Ilse M LuckeFilip Eftimov
Nov 23, 2017·Arquivos de neuro-psiquiatria·José Luiz PedrosoOrlando G Barsottini
Apr 18, 2020·Neurology. Neuroimmunology and Neuroinflammation·Marieke van der ZwanBart C Jacobs
Jan 23, 2021·Journal of Nephrology·Irene FaravelliClaudio Ponticelli

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